Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/8585
The viral transcription group determines the HLA class I cellular immune response against human respiratory syncytial virus
Mol Cell Proteomics. 2015 Apr;14(4):893-904. doi: 10.1074/mcp.M114.045401. Epub 2015 Jan 29.
The cytotoxic T-lymphocyte-mediated killing of virus-infected cells requires previous recognition of short viral antigenic peptides bound to human leukocyte antigen class I molecules that are exposed on the surface of infected cells. The cytotoxic T-lymphocyte response is critical for the clearance of human respiratory syncytial virus infection. In this study, naturally processed viral human leukocyte antigen class I ligands were identified with mass spectrometry analysis of complex human leukocyte antigen-bound peptide pools isolated from large amounts of human respiratory syncytial virus-infected cells. Acute antiviral T-cell response characterization showed that viral transcription determines both the immunoprevalence and immunodominance of the human leukocyte antigen class I response to human respiratory syncytial virus. These findings have clear implications for antiviral vaccine design.
Amino Acid Sequence | Animals | Antigen Presentation | Cell Extracts | Cell Line | Histocompatibility Antigens Class I | Humans | Immunity, Cellular | Immunodominant Epitopes | Ligands | Mice, Transgenic | Molecular Sequence Data | Peptides | Proteome | Respiratory Syncytial Virus, Human | T-Lymphocytes | Tandem Mass Spectrometry | Transcription, Genetic
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