Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7965
Título
Pitfalls in spontaneous in vitro transformation of human mesenchymal stem cells
Autor(es)
Garcia, S | Bernad, A | Martín, M C | Cigudosa, J C | Garcia-Castro, Javier ISCIII | de la Fuente, R
Fecha de publicación
2010-05-15
Cita
Exp Cell Res. 2010 May 15;316(9):1648-50.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Spontaneous in vitro transformation of human primary cells was, and continues to be, a scarcely described phenomenon. Only the description of the generation of the HaCAT cell line [1] is a canonical example, worldwide accepted. More recent examples included the emergence of tumorogenic populations upon in vitro culture of fetal human mesenchymal stem cells (hMSC), induced by GM-CSF and IL-4, [2] and bone marrow hMSC [3]. Other examples have also been reported after very long-term in vitro culture of telomerized hMSCTerT [4]. In this scenario, our previous results [5-7] were only a new observation to be added to this list. Only very recently similar results have been published [8], reporting spontaneous malignant transformation in 46 % of bone marrow–derived hMSC long-term cultures (5–106 weeks). However, other authors reported opposite results.
MESH
Versión en línea
DOI
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