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dc.contributor.author | García-Pérez, Javier | |
dc.contributor.author | Lope Carvajal, Virginia | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.contributor.author | Molina, Antonio José | |
dc.contributor.author | Tardón, Adonina | |
dc.contributor.author | Díaz Santos, María Angustias | |
dc.contributor.author | Ardanaz, Eva | |
dc.contributor.author | O'Callaghan-Gordo, Cristina | |
dc.contributor.author | Altzibar, Jone M | |
dc.contributor.author | Gómez-Acebo, Inés | |
dc.contributor.author | Moreno, Víctor | |
dc.contributor.author | Peiró, Rosana | |
dc.contributor.author | Marcos-Gragera, Rafael | |
dc.contributor.author | Kogevinas, Manolis | |
dc.contributor.author | Aragones, Nuria | |
dc.contributor.author | Lopez-Abente, Gonzalo | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.date.accessioned | 2019-06-26T09:03:20Z | |
dc.date.available | 2019-06-26T09:03:20Z | |
dc.date.issued | 2018-06 | |
dc.identifier.citation | Environ Pollut. 2018 Jun;237:559-568. | es_ES |
dc.identifier.issn | 0269-7491 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7802 | |
dc.description.abstract | Breast cancer is the most frequent tumor in women worldwide, although well-established risk factors account for 53%-55% of cases. Therefore, other risk factors, including environmental exposures, may explain the remaining variation. Our objective was to assess the relationship between risk of breast cancer and residential proximity to industries, according to categories of industrial groups and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). Using the current residence of cases and controls, this study was restricted to small administrative divisions, including both breast cancer cases (452) and controls (1511) in the 10 geographical areas recruiting breast cancer cases. Distances were calculated from the respective woman's residences to the 116 industries located in the study area. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (between 1 km and 3 km) to industrial plants, adjusting for matching variables and other confounders. Excess risk (OR; 95%CI) of breast cancer was found near industries overall (1.30; 1.00-1.69 at 3 km), particularly organic chemical industry (2.12; 1.20-3.76 at 2.5 km), food/beverage sector (1.87; 1.26-2.78 at 3 km), ceramic (4.71; 1.62-13.66 at 1.5 km), surface treatment with organic solvents (2.00; 1.23-3.24 at 3 km), and surface treatment of plastic and metals (1.51; 1.06-2.14 at 3 km). By pollutants, the excess risk (OR; 95%CI) was detected near industries releasing pesticides (2.09; 1.14-3.82 at 2 km), and dichloromethane (2.09; 1.28-3.40 at 3 km). Our results suggest a possible increased risk of breast cancer in women living near specific industrial plants and support the need for more detailed exposure assessment of certain agents released by these plants. | es_ES |
dc.description.sponsorship | The authors thank all those who took part in this study providing questionnaire data. The study was partially funded by the “Acción Transversal del Cáncer", approved on the Spanish Ministry Council on the 11th October 2007, by the Scientific Foundation of the Spanish Association Against Cancer (Fundación Científica de la Asociación Española Contra el Cáncer (AECC) – EVP-1178/14), by the Spain's Health Research Fund (Fondo de Investigación Sanitaria - FIS 12/01416), by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359 PS09/01286-León, PS09/00773-Cantabria, PS09/02078-Huelva, PS09/01903-Valencia, PS09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/00613, PI15/00069, PI15/00914, PI15/01032), by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)), by the Fundación Marqués de Valdecilla (API 10/09), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Junta de Castilla y León (LE22A10-2), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Regional Government of the Basque Country, by the Recercaixa (2010ACUP 00310), by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Catalan Government DURSI grant 2017SGR723, by the University of Oviedo, and by the Fundación Caja de Ahorros de Asturias. ISGlobal is a member of the CERCA Program, Generalitat de Catalunya. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | SMUR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Breast cancer | es_ES |
dc.subject | Case-control study | es_ES |
dc.subject | Endocrine disrupting chemicals | es_ES |
dc.subject | Industrial pollution | es_ES |
dc.subject | Pesticides | es_ES |
dc.subject | Residential proximity | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Breast Neoplasms | es_ES |
dc.subject.mesh | Case-Control Studies | es_ES |
dc.subject.mesh | Environmental Exposure | es_ES |
dc.subject.mesh | Environmental Pollution | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Geography | es_ES |
dc.subject.mesh | Housing | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Industry | es_ES |
dc.subject.mesh | Logistic Models | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Odds Ratio | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.title | Risk of breast cancer and residential proximity to industrial installations: New findings from a multicase-control study (MCC-Spain) | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 29524878 | es_ES |
dc.format.volume | 237 | es_ES |
dc.format.page | 559-568 | es_ES |
dc.identifier.doi | 10.1016/j.envpol.2018.02.065 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España) | |
dc.contributor.funder | Fundación Marqués de Valdecilla | |
dc.contributor.funder | Regional Government of Andalusia (España) | |
dc.contributor.funder | Junta de Castilla y León (España) | |
dc.contributor.funder | Generalitat Valenciana (España) | |
dc.contributor.funder | Basque Government (España) | |
dc.contributor.funder | Fundación La Caixa | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Government of Catalonia (España) | |
dc.contributor.funder | University of Oviedo (España) | |
dc.contributor.funder | Fundación Caja de Ahorros de Asturias | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1873-6424 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.envpol.2018.02.065 | es_ES |
dc.identifier.journal | Environmental pollution (Barking, Essex : 1987) | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/EVP-1178/14 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/12/01416) | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1770 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/0533 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/1359 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/01286 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/00773 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/02078 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/01903 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/01662 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01403 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01889 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/00226 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01810 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/02213 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00488 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00265 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/01270 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00715 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/00150 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/01219 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/00613 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00069 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/00914 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI15/01032 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0036/0036 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/API10/09 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI-0571-2009 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI-0306-2011 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/salud201200057018tra | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/LE22A10-2 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/AP_061/10 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/2010ACUP00310 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/FOOD-CT-2006-036224-HIWATE | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/DECSI 2017SGR723 | es_ES |
dc.rights.accessRights | open access | es_ES |