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dc.contributor.authorLopez-Huertas, Maria Rosa 
dc.contributor.authorCallejas, Sergio 
dc.contributor.authorAbia, David
dc.contributor.authorDopazo, Ana 
dc.contributor.authorAlcamí, José 
dc.contributor.authorCoiras, Mayte 
dc.date.accessioned2019-05-29T08:57:43Z
dc.date.available2019-05-29T08:57:43Z
dc.date.issued2009
dc.identifier.citationNucleic Acids Res. 2010 Jun;38(10):3287-307.es_ES
dc.identifier.issn1742-4690es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7692
dc.description1 page.-- Poster presentation.es_ES
dc.description.abstractThe human immunodeficiency virus type 1 (HIV-1) encodes the 110 amino acid-pleiotropic nuclear transcriptional activator Tat that is not only essential for efficient elongation of viral transcripts, but also regulates both cellular protein and gene expression. Tat encoding gene consists of two spliced exons separated in the HIV-1 genome by more than 2.300 nucleotides. First 72 residues at the N-terminal encoded by the first exon appear to be sufficient for transcriptional activity, but the integrity of the coding second exon in most lentiviral genomes suggests that it should have some biological importance. In this work, we demonstrate that the second exon completes Tat function.es_ES
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectHuman Immunodeficiency Viruses_ES
dc.subjectJurkat Celles_ES
dc.subjectBinding Strengthes_ES
dc.subjectCellular Movementes_ES
dc.titleModifications in host cell structure and functions mediated by Tat intracellular expression are greatly dependent on the second exones_ES
dc.typePósteres_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.format.volume6es_ES
dc.format.numberSuppl 2es_ES
dc.format.pageP1es_ES
dc.identifier.doi10.1186/1742-4690-6-S2-P1es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://www.doi.org/10.1186/1742-4690-6-S2-P1es_ES
dc.identifier.journalRetrovirologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Genómica
dc.repisalud.institucionISCIIIes_ES
dc.repisalud.institucionCNIC
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
This item is licensed under a: Atribución-NoComercial-CompartirIgual 4.0 Internacional