Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7692
Título
Modifications in host cell structure and functions mediated by Tat intracellular expression are greatly dependent on the second exon
Autor(es)
Lopez-Huertas, Maria Rosa ISCIII | Callejas, Sergio CNIC | Abia, David | Dopazo, Ana CNIC | Alcamí, José ISCIII | Coiras, Mayte ISCIII
Fecha de publicación
2009
Cita
Nucleic Acids Res. 2010 Jun;38(10):3287-307.
Idioma
Inglés
Tipo de documento
conference poster
Resumen
The human immunodeficiency virus type 1 (HIV-1) encodes the 110 amino acid-pleiotropic nuclear transcriptional activator Tat that is not only essential for efficient elongation of viral transcripts, but also regulates both cellular protein and gene expression. Tat encoding gene consists of two spliced exons separated in the HIV-1 genome by more than 2.300 nucleotides. First 72 residues at the N-terminal encoded by the first exon appear to be sufficient for transcriptional activity, but the integrity of the coding second exon in most lentiviral genomes suggests that it should have some biological importance. In this work, we demonstrate that the second exon completes Tat function.
Palabras clave
Descripción
1 page.-- Poster presentation.
Versión en línea
DOI
Aparece en las colecciones