Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7354
Título
The Epicardium in the Embryonic and Adult Zebrafish
Autor(es)
Peralta, Marina CNIC | Gonzalez-Rosa, Juan Manuel CNIC | Marques, Ines Joao CNIC | Mercader, Nadia CNIC
Fecha de publicación
2014-04-11
Cita
J Dev Biol. 2014; 2(2):101-116
Idioma
Inglés
Tipo de documento
journal article
Resumen
The epicardium is the mesothelial outer layer of the vertebrate heart. It plays an important role during cardiac development by, among other functions, nourishing the underlying myocardium, contributing to cardiac fibroblasts and giving rise to the coronary vasculature. The epicardium also exerts key functions during injury responses in the adult and contributes to cardiac repair. In this article, we review current knowledge on the cellular and molecular mechanisms underlying epicardium formation in the zebrafish, a teleost fish, which is rapidly gaining status as an animal model in cardiovascular research, and compare it with the mechanisms described in other vertebrate models. We moreover describe the expression patterns of a subset of available zebrafish Wilms' tumor 1 transgenic reporter lines and discuss their specificity, applicability and limitations in the study of epicardium formation.
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- Nombre:
- EpicardiumEmbryonicAdultZebraf ...
- Tamaño:
- 20.13Mb
- Formato:
- Video QuickTime