Mostrar el registro sencillo del ítem
dc.contributor.author | Peralta, Marina | |
dc.contributor.author | Gonzalez-Rosa, Juan Manuel | |
dc.contributor.author | Marques, Ines Joao | |
dc.contributor.author | Mercader, Nadia | |
dc.date.accessioned | 2019-03-18T14:23:41Z | |
dc.date.available | 2019-03-18T14:23:41Z | |
dc.date.issued | 2014-04-11 | |
dc.identifier.citation | J Dev Biol. 2014; 2(2):101-116 | es_ES |
dc.identifier.issn | 2221-3759 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7354 | |
dc.description.abstract | The epicardium is the mesothelial outer layer of the vertebrate heart. It plays an important role during cardiac development by, among other functions, nourishing the underlying myocardium, contributing to cardiac fibroblasts and giving rise to the coronary vasculature. The epicardium also exerts key functions during injury responses in the adult and contributes to cardiac repair. In this article, we review current knowledge on the cellular and molecular mechanisms underlying epicardium formation in the zebrafish, a teleost fish, which is rapidly gaining status as an animal model in cardiovascular research, and compare it with the mechanisms described in other vertebrate models. We moreover describe the expression patterns of a subset of available zebrafish Wilms' tumor 1 transgenic reporter lines and discuss their specificity, applicability and limitations in the study of epicardium formation. | es_ES |
dc.description.sponsorship | This work was supported by the Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III and grants S2010/BMD-2321 FIBROTEAM, BFU201125297 and TerCel S2010 to Nadia Mercader, AP2008-00546 to Juan Manuel González-Rosa and | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Development | es_ES |
dc.subject | Epicardium | es_ES |
dc.subject | Proepicardium | es_ES |
dc.subject | Regeneration | es_ES |
dc.subject | wt1a | es_ES |
dc.subject | wt1b | es_ES |
dc.subject | Zebrafish | es_ES |
dc.title | The Epicardium in the Embryonic and Adult Zebrafish | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 24926432 | es_ES |
dc.format.volume | 2 | es_ES |
dc.format.number | 2 | es_ES |
dc.format.page | 101-116 | es_ES |
dc.identifier.doi | 10.3390/jdb2020101 | es_ES |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/jdb2020101 | es_ES |
dc.identifier.journal | Journal of developmental biology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Desarrollo del Epicardio y su Papel en la Regeneración | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BFU2011-25297 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/AP2008-00546 | es_ES |
dc.rights.accessRights | open access | es_ES |