Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7227
Título
Protein Localization at Mitochondria-ER Contact Sites in Basal and Stress Conditions
Autor(es)
Fecha de publicación
2017
Cita
Front Cell Dev Biol. 2017; 5:107
Idioma
Inglés
Tipo de documento
journal article
Resumen
Mitochondria-endoplasmic reticulum (ER) contacts (MERCs) are sites at which the outer mitochondria membrane and the Endoplasmic Reticulum surface run in parallel at a constant distance. The juxtaposition between these organelles determines several intracellular processes such as to name a few, Ca2+ and lipid homeostasis or autophagy. These specific tasks can be exploited thanks to the enrichment (or re-localization) of dedicated proteins at these interfaces. Recent proteomic studies highlight the tissue specific composition of MERCs, but the overall mechanisms that control MERCs plasticity remains unclear. Understanding how proteins are targeted at these sites seems pivotal to clarify such contextual function of MERCs. This review aims to summarize the current knowledge on protein localization at MERCs and the possible contribution of the mislocalization of MERCs components to human disorders.
Palabras clave
ER stress | Lipid rafts | Mitochondria-ER contact sites | Post-translational modifications | Protein targeting
Versión en línea
DOI
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- Nombre:
- ProteinLocalizationMitochondri ...
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- 1.301Mb
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- Artículo