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dc.contributor.authorIlacqua, Nicolò
dc.contributor.authorSanchez-Alvarez, Miguel 
dc.contributor.authorBachmann, Magdalena
dc.contributor.authorCostiniti, Veronica
dc.contributor.authordel Pozo, Miguel Angel 
dc.contributor.authorGiacomello, Marta
dc.identifier.citationFront Cell Dev Biol. 2017; 5:107es_ES
dc.description.abstractMitochondria-endoplasmic reticulum (ER) contacts (MERCs) are sites at which the outer mitochondria membrane and the Endoplasmic Reticulum surface run in parallel at a constant distance. The juxtaposition between these organelles determines several intracellular processes such as to name a few, Ca2+ and lipid homeostasis or autophagy. These specific tasks can be exploited thanks to the enrichment (or re-localization) of dedicated proteins at these interfaces. Recent proteomic studies highlight the tissue specific composition of MERCs, but the overall mechanisms that control MERCs plasticity remains unclear. Understanding how proteins are targeted at these sites seems pivotal to clarify such contextual function of MERCs. This review aims to summarize the current knowledge on protein localization at MERCs and the possible contribution of the mislocalization of MERCs components to human disorders.es_ES
dc.description.sponsorshipThis work was supported by CARIPARO Starting Grant 2016 AIFbiol (toMG) and DiBio Departmental Research Project PRID Seed 2017 (to MG); MD received support from grants SAF201451876-R from MINECO (Spanish Ministry of Economy and Competitiveness) and 15-0404 from the Worldwide Cancer Research Foundation. MS-Á is recipient of an IPP-CNIC postdoctoral fellow award. The CNIC is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.publisherFrontiers Media es_ES
dc.subjectER stresses_ES
dc.subjectLipid raftses_ES
dc.subjectMitochondria-ER contact siteses_ES
dc.subjectPost-translational modificationses_ES
dc.subjectProtein targetinges_ES
dc.titleProtein Localization at Mitochondria-ER Contact Sites in Basal and Stress Conditionses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderFondazione Cariparo
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderWorldwide Cancer Research Foundation
dc.contributor.funderFundación ProCNIC 
dc.identifier.journalFrontiers in cell and developmental biologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Señalización por Integrinases_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 4.0 Internacional
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