Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7212
Title
Aurora A controls CD8+ T cell cytotoxic activity and antiviral response
Author(s)
Bustos-Morán, Eugenio | Blas-Rus, Noelia CNIC | Alcaraz-Serna, Ana | Iborra, Salvador CNIC | González-Martínez, José | Malumbres Martinez, Marcos CNIO | Sanchez-Madrid, Francisco CNIC
Date issued
2019-02-18
Citation
Sci Rep. 2019; 9(1):2211
Language
Inglés
Document type
journal article
Abstract
Aurora A is a serine/threonine kinase whose role in cell cycle progression and tumour generation has been widely studied. Recent work has revealed an unexpected function for Aurora A during CD4+ T cell activation and, also, in graft versus host disease development. However, it remains unknown whether Aurora A is involved in CD8+ T cell effector function and in cytotoxic T lymphocyte-mediated antiviral response. Here, we show that Aurora A chemical inhibition leads to an impairment of both the peptide-specific cytotoxicity and the degranulation activity of CD8+ T cells. This finding was similarly proven for both mice and human CD8+ CTL activity. As a result of Aurora A blockade, we detected a reduction in the expression induced by T cell activation of genes classically related to the effector function of cytotoxic T lymphocytes such as granzyme B or perforin1. Finally, we have found that Aurora A is necessary for CD8+ T cell-mediated antiviral response, in an in vivo model of vaccinia virus infection. Thus, we can conclude that Aurora A activity is, indeed, needed for the proper effector function of cytotoxic T lymphocytes and for their activity against viral threats.
Online version
DOI
Collections
- Investigación > CNIO > Grupos de investigación
- Investigación > CNIC > Grupos de investigación
- Investigación > IIS > i+12 - Instituto de Investigación Hospital 12 de Octubre (Madrid)
- Investigación > IIS > IIS-PRINCESA - Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (Madrid)