Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7061
All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997-2010
Hernando Sebastian, Victoria ISCIII | Alejos, Belen ISCIII | Monge Corella, Susana ISCIII | Berenguer, Juan | Anta, Lourdes | Vinuesa, David | Palacios, Rosario | Muga, Roberto | Moreno, Santiago | Jarrin-Vera, Inmaculada ISCIII
BMC Infect Dis. 2013 Aug 20;13:382.
BACKGROUND: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIV-infected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. METHODS: We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 person-years (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. RESULTS: Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997-2003). CONCLUSION: Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection.
Acquired Immunodeficiency Syndrome | Adult | Cohort Studies | Female | Humans | Male | Middle Aged | Risk Factors | Spain | Young Adult
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