Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7046
Human transmissible spongiform encephalopathies in eleven countries: diagnostic pattern across time, 1993-2002
Pedro-Cuesta, Jesus de ISCIII | Glatzel, Markus | Almazan-Isla, Javier ISCIII | Stoeck, Katharina | Mellina, Vittorio | Puopolo, Maria | Pocchiari, Maurizio | Zerr, Inga | Kretszchmar, Hans A | Brandel, Jean-Philippe | Delasnerie-Lauprêtre, Nicole | Alpérovitch, Annick | Van Duijn, Cornelia | Sánchez-Juan, Pascual | Collins, Steven | Lewis, Victoria | Jansen, Gerard H | Coulthart, Michael B | Gelpi, Ellen | Budka, Herbert | Mitrova, Eva
BMC Public Health. 2006 Nov 10;6:278.
BACKGROUND: The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries. METHODS: From data collected for surveillance purposes, we describe annual proportions of deaths due to different human transmissible spongiform encephalopathies in eleven EUROCJD-consortium countries over the period 1993-2002, as well as variations in the use of diagnostic tests. Using logistic models we quantified international differences and changes across time. RESULTS: In general, pre-mortem use of diagnostic investigations increased with time. International differences in pathological confirmation of sporadic Creutzfeldt-Jakob disease, stable over time, were evident. Compared to their counterparts, some countries displayed remarkable patterns, such as: 1) the high proportion, increasing with time, of variant Creutzfeldt-Jakob disease in the United Kingdom, (OR 607.99 95% CI 84.72-4363.40), and France (OR 18.35, 95% CI 2.20-152.83); 2) high, decreasing proportions of iatrogenic Creutzfeldt-Jakob disease in France, (OR 5.81 95% CI 4.09-8.24), and the United Kingdom, (OR 1.54 95% CI 1.03-2.30); and, 3) high and stable ratios of genetic forms in Slovakia (OR 21.82 95% CI 12.42-38.33) and Italy (OR 2.12 95% CI 1.69-2.68). CONCLUSION: Considerable international variation in aetiological subtypes of human transmissible spongiform encephalopathies was evident over the observation period. With the exception of variant Creutzfeldt-Jakob disease and iatrogenic Creutzfeldt-Jakob disease in France and the United Kingdom, these differences persisted across time.
Australia | Canada | Creutzfeldt-Jakob Syndrome | Cross-Cultural Comparison | Electroencephalography | Europe | France | Genotype | Humans | Iatrogenic Disease | Internationality | Italy | Magnetic Resonance Imaging | Population Surveillance | Prion Proteins | Prions | Registries | Slovakia | Time | United Kingdom
Files in this item
- HumanTransmissibleSpongiformEn ...