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dc.contributor.authorGarcia-Esquinas, Esther
dc.contributor.authorGuinó, Elisabeth
dc.contributor.authorCastaño-Vinyals, Gemma
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorLlorca, Javier
dc.contributor.authorAltzibar, Jone M
dc.contributor.authorPeiró-Pérez, Rosana
dc.contributor.authorMartín, Vicente
dc.contributor.authorMoreno-Iribas, Concepción
dc.contributor.authorTardón, Adonina
dc.contributor.authorCaballero, Francisco Javier
dc.contributor.authorPuig-Vives, Montse
dc.contributor.authorGuevara, Marcela
dc.contributor.authorVilla, Tania Fernández
dc.contributor.authorSalas, Dolores
dc.contributor.authorAmiano, Pilar
dc.contributor.authorDierssen-Sotos, Trinidad
dc.contributor.authorPastor-Barriuso, Roberto 
dc.contributor.authorSala, María
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorAragones, Nuria 
dc.contributor.authorMoreno, Víctor
dc.contributor.authorPollan-Santamaria, Marina 
dc.date.accessioned2018-12-13T12:06:38Z
dc.date.available2018-12-13T12:06:38Z
dc.date.issued2015-04-29
dc.identifier.citationActa Diabetol. 2016; 53: 99–107.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6848
dc.description.abstractAIMS: The aim of this study was to evaluate the association of diabetes and diabetes treatment with risk of postmenopausal breast cancer. METHODS: Histologically confirmed incident cases of postmenopausal breast (N = 916) cancer were recruited from 23 Spanish public hospitals. Population-based controls (N = 1094) were randomly selected from primary care center lists within the catchment areas of the participant hospitals. ORs (95 % CI) were estimated using mixed-effects logistic regression models, using the recruitment center as a random effect term. Breast tumors were classified into hormone receptor positive (ER+ or PR+), HER2+ and triple negative (TN). RESULTS: Diabetes was not associated with the overall risk of breast cancer (OR 1.09; 95 % CI 0.82-1.45), and it was only linked to the risk of developing TN tumors: Among 91 women with TN tumors, 18.7 % were diabetic, while the corresponding figure among controls was 9.9 % (OR 2.25; 95 % CI 1.22-4.15). Regarding treatment, results showed that insulin use was more prevalent among diabetic cases (2.5 %) as compared to diabetic controls (0.7 %); OR 2.98; 95 % CI 1.26-7.01. They also showed that, among diabetics, the risk of developing HR+/HER2- tumors decreased with longer metformin use (ORper year 0.89; 95 % CI 0.81-0.99; based on 24 cases and 43 controls). CONCLUSION: This study reinforces the need to correctly classify breast cancers when studying their association with diabetes. Given the low survival rates in women diagnosed with TN breast tumors and the potential impact of diabetes control on breast cancer prevention, more studies are needed to better characterize this association.es_ES
dc.description.sponsorshipThis work was supported by research Grants from Spain´s Health Research Fund Fondo de Investigación Sanitaria (PI12/00488, PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00265, PI12/01270, PI12/00715, PI12/00150), Fundación Marqués de Valdecilla (API 10/09), ICGC International Cancer Genome Consortium CLL, Junta de Castilla y León (LE22A10-2), Consejería de Salud of the Junta de Andalucía (PI-0571), Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), Recercaixa (2010ACUP 00310), Regional Government of the Basque Country by European Commission GrantsFOOD-CT-2006-036224-HIWATE, Spanish Association Against Cancer (AECC) Scientific Foundation and the Catalan Government DURSI Grant 2014SGR647es_ES
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBreast canceres_ES
dc.subjectDiabetes Mellituses_ES
dc.subjectInsulines_ES
dc.subjectMetformines_ES
dc.subjectTriple-negative breast neoplasmses_ES
dc.subject.meshAdult es_ES
dc.subject.meshBreast Neoplasms es_ES
dc.subject.meshCase-Control Studies es_ES
dc.subject.meshDiabetes Mellitus es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshIncidence es_ES
dc.subject.meshMetformin es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPostmenopause es_ES
dc.subject.meshSpain es_ES
dc.titleAssociation of diabetes and diabetes treatment with incidence of breast canceres_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-4.0 Internacional*
dc.identifier.pubmedID25916213es_ES
dc.format.volume53es_ES
dc.format.number1es_ES
dc.format.page99-107es_ES
dc.identifier.doi10.1007/s00592-015-0756-6es_ES
dc.contributor.funderFondo de Investigaciones Sanitariases_ES
dc.contributor.funderFundación Marqués de Valdecillaes_ES
dc.contributor.funderInternational Cancer Genome Consortium CLLes_ES
dc.contributor.funderGobierno de Castilla y Leónes_ES
dc.contributor.funderGobierno de Andaluciaes_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderRecercaixaes_ES
dc.contributor.funderGobierno Vascoes_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderAsociación Española contra el Cánceres_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1432-5233es_ES
dc.identifier.journalActa diabetologicaes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00488es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1770es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/0533es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/1359es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/00773es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01286es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01903es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/02078es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01662es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01403es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01889es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/00226es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/01810es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI11/02213es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00265es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/01270es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00715es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/00150es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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