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dc.contributor.author | Pernas, Maria | |
dc.contributor.author | Casado, Concepcion | |
dc.contributor.author | Arcones, Carolina | |
dc.contributor.author | Llano, Anuska | |
dc.contributor.author | Sanchez-Merino, Victor | |
dc.contributor.author | Mothe, Beatriz | |
dc.contributor.author | Vicario, José L | |
dc.contributor.author | Grau, Eulalia | |
dc.contributor.author | Ruiz, Lidia | |
dc.contributor.author | Sánchez, Jorge | |
dc.contributor.author | Telenti, Amalio | |
dc.contributor.author | Yuste-Herranz, Maria Eloisa | |
dc.contributor.author | Brander, Christian | |
dc.contributor.author | Lopez-Galindez, Luis Cecilio | |
dc.date.accessioned | 2018-12-12T15:01:22Z | |
dc.date.available | 2018-12-12T15:01:22Z | |
dc.date.issued | 2012-02-24 | |
dc.identifier.citation | PLoS One. 2012;7(2):e31928 | es_ES |
dc.identifier.issn | 1932-6203 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/6828 | |
dc.description.abstract | OBJECTIVE: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient. METHODOLOGY AND PRINCIPAL FINDINGS: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controller (LTNP-EC). The individual contained both viruses and maintained undetectable viral loads for >20 years and he did not express any of the described host genetic polymorphisms associated with viral control. None of four full-length gp160 recombinants derived from the LTNP-EC replicated in heterologous peripheral blood mononuclear cells. CTL responses after SI were maintained in two samples separated by 9 years and they were higher in breadth and magnitude than responses seen in most of 250 treatment naïve patients and also 25 controller subjects. The LTNP-EC showed a neutralization response, against 4 of the 6 viruses analyzed, superior to other ECs. CONCLUSIONS: The study demonstrated that a strong and sustained cellular and humoral immune response and low replicating viruses are associated with viral control in the superinfected LTNP-EC. | es_ES |
dc.description.sponsorship | This work was supported by grants SAF 2007-61036 and SAF 2010-17226, by Fundacion para la Investigacion y Prevencion del SIDA en España (FIPSE) grants 36558/06, 36641/07, 36779/08, 360766/09 and 360737/09, and by the United States National Institute of Health NIH-NIAID contract N01-AI-30024. Support by the Red Temática Cooperativa de Investigación en SIDA (Red de grupos 173) of the Fondo de Investigaciones Sanitarias de la Seguridad Social (FISss) is appreciated. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science (PLOS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Antiviral Agents | es_ES |
dc.subject.mesh | CD4-Positive T-Lymphocytes | es_ES |
dc.subject.mesh | Chemokines | es_ES |
dc.subject.mesh | Disease Progression | es_ES |
dc.subject.mesh | Genotype | es_ES |
dc.subject.mesh | HIV-1 | es_ES |
dc.subject.mesh | Haplotypes | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Immune System | es_ES |
dc.subject.mesh | Leukocytes, Mononuclear | es_ES |
dc.subject.mesh | Likelihood Functions | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Mutation | es_ES |
dc.subject.mesh | Polymorphism, Genetic | es_ES |
dc.subject.mesh | Recombinant Proteins | es_ES |
dc.subject.mesh | Time Factors | es_ES |
dc.subject.mesh | Viral Load | es_ES |
dc.subject.mesh | Virus Replication | es_ES |
dc.title | Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 22384103 | es_ES |
dc.format.volume | 7 | es_ES |
dc.format.number | 2 | es_ES |
dc.format.page | e31928 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0031928 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Fundación para la Investigación y la Prevención del Sida en España | |
dc.contributor.funder | National Institutes of Health (Estados Unidos) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1932-6203 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0031928 | es_ES |
dc.identifier.journal | PloS one | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF-2007-61036 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF-2010-17226 | es_ES |
dc.rights.accessRights | open access | es_ES |