Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/6828
Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller
Pernas, Maria ISCIII | Casado, Concepcion ISCIII | Arcones, Carolina ISCIII | Llano, Anuska | Sanchez-Merino, Victor ISCIII | Mothe, Beatriz | Vicario, José L | Grau, Eulalia | Ruiz, Lidia | Sánchez, Jorge | Telenti, Amalio | Yuste-Herranz, Maria Eloisa ISCIII | Brander, Christian | Lopez-Galindez, Luis Cecilio ISCIII
PLoS One. 2012;7(2):e31928
OBJECTIVE: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient. METHODOLOGY AND PRINCIPAL FINDINGS: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controller (LTNP-EC). The individual contained both viruses and maintained undetectable viral loads for >20 years and he did not express any of the described host genetic polymorphisms associated with viral control. None of four full-length gp160 recombinants derived from the LTNP-EC replicated in heterologous peripheral blood mononuclear cells. CTL responses after SI were maintained in two samples separated by 9 years and they were higher in breadth and magnitude than responses seen in most of 250 treatment naïve patients and also 25 controller subjects. The LTNP-EC showed a neutralization response, against 4 of the 6 viruses analyzed, superior to other ECs. CONCLUSIONS: The study demonstrated that a strong and sustained cellular and humoral immune response and low replicating viruses are associated with viral control in the superinfected LTNP-EC.
Antiviral Agents | CD4-Positive T-Lymphocytes | Chemokines | Disease Progression | Genotype | HIV-1 | Haplotypes | Humans | Immune System | Leukocytes, Mononuclear | Likelihood Functions | Male | Mutation | Polymorphism, Genetic | Recombinant Proteins | Time Factors | Viral Load | Virus Replication
Files in this item
- Low-ReplicatingVirusesAndStron ...