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dc.contributor.authorde Miguel-Díez, Javier
dc.contributor.authorLópez-de-Andrés, Ana
dc.contributor.authorJiménez-García, Rodrigo
dc.contributor.authorPuente-Maestu, Luis
dc.contributor.authorJiménez-Trujillo, Isabel
dc.contributor.authorHernández-Barrera, Valentín
dc.contributor.authorResino, Salvador 
dc.contributor.authorÁlvaro-Meca, Alejandro
dc.identifier.citation2016; 11(11): e0166421.es_ES
dc.description.abstractPURPOSE: The aim of this study was to estimate trends of incidence of hospital admissions and in-hospital mortality (IHM) in HIV-infected patients with COPD in the combination antiretroviral therapy (cART) era in Spain (1997-2012). METHODS: A retrospective study with data from nationwide population-based COPD diagnoses in the Spanish Minimum Basic Data Set (MBDS) was performed. We established groups according to their HIV and HCV infections: 1) HIV-uninfected patients; 2) HIV-infected patients (with or without HCV coinfection). RESULTS: 1,580,207 patients discharge with a COPD diagnosis were included in the study, 8902 of them were HIV-infected patients (5000 HIV-monoinfected patients and 3902 HIV/HCV-coinfected patients). The HIV-infected patients had higher incidence rates of hospital admissions for COPD than the HIV-uninfected patients during the study period. The HIV-monoinfected patients had higher rates of hospitalizations for COPD than the HIV/HCV-coinfected patients in the early-period cART (1997-1999), but these rates decreased in the first group and increased in the second, being even similar in both groups in the late-period cART (2004-2011). On the other hand, the HIV-infected patients with COPD had higher IHM than the HIV-uninfected patients with COPD. The mortality rates were higher in the HIV-monoinfected patients with COPD than in the HIV/HCV-coinfected patients with COPD in the early-period cART; however, in the late-period cART, the mortality rates trends seems higher in the HIV/HCV group. The likelihood of death in HIV/HCV-coinfected patients with COPD was similar to than in HIV-monoinfected patients with COPD. CONCLUSIONS: Incidence of hospital admissions for COPD and IHM have decreased among HIV-monoinfected individuals but have increased steadily among HIV/HCV-coinfected individuals in the cART era.es_ES
dc.description.sponsorshipThis study forms part of research funded by the FIS (Fondo de Investigaciones Sanitarias—Health Research Fund, Instituto de Salud Carlos III grants no. PI11/00245 to SR, PI12/00019 to AAM and PI12/02734 to LPM) co-financed by the European Union through the Fondo Europeo de Desarrollo Regional (FEDER, “Una manera de hacer Europa”) and by the Grupo de Excelencia Investigadora URJC-Banco Santander N°30VCPIGI03: Investigación traslacional en el proceso de salud—enfermedad (ITPSE) to RJG. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.subjectAntiretroviral Therapy, Highly Activees_ES
dc.subjectAntiviral Agentses_ES
dc.subjectHIV Infectionses_ES
dc.subjectHepatitis C, Chronices_ES
dc.subjectHospital Mortalityes_ES
dc.subjectMiddle Agedes_ES
dc.subjectPulmonary Disease, Chronic Obstructivees_ES
dc.subjectRetrospective Studieses_ES
dc.subjectSurvival Analysises_ES
dc.titleTrends in Epidemiology of COPD in HIV-Infected Patients in Spain (1997–2012)es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderKing Juan Carlos University (España) 
dc.contributor.funderBanco Santander 
dc.identifier.journalPLOS ONEes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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