Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/5748
Trends in Epidemiology of COPD in HIV-Infected Patients in Spain (1997–2012)
2016; 11(11): e0166421.
PURPOSE: The aim of this study was to estimate trends of incidence of hospital admissions and in-hospital mortality (IHM) in HIV-infected patients with COPD in the combination antiretroviral therapy (cART) era in Spain (1997-2012). METHODS: A retrospective study with data from nationwide population-based COPD diagnoses in the Spanish Minimum Basic Data Set (MBDS) was performed. We established groups according to their HIV and HCV infections: 1) HIV-uninfected patients; 2) HIV-infected patients (with or without HCV coinfection). RESULTS: 1,580,207 patients discharge with a COPD diagnosis were included in the study, 8902 of them were HIV-infected patients (5000 HIV-monoinfected patients and 3902 HIV/HCV-coinfected patients). The HIV-infected patients had higher incidence rates of hospital admissions for COPD than the HIV-uninfected patients during the study period. The HIV-monoinfected patients had higher rates of hospitalizations for COPD than the HIV/HCV-coinfected patients in the early-period cART (1997-1999), but these rates decreased in the first group and increased in the second, being even similar in both groups in the late-period cART (2004-2011). On the other hand, the HIV-infected patients with COPD had higher IHM than the HIV-uninfected patients with COPD. The mortality rates were higher in the HIV-monoinfected patients with COPD than in the HIV/HCV-coinfected patients with COPD in the early-period cART; however, in the late-period cART, the mortality rates trends seems higher in the HIV/HCV group. The likelihood of death in HIV/HCV-coinfected patients with COPD was similar to than in HIV-monoinfected patients with COPD. CONCLUSIONS: Incidence of hospital admissions for COPD and IHM have decreased among HIV-monoinfected individuals but have increased steadily among HIV/HCV-coinfected individuals in the cART era.
Adult | Antiretroviral Therapy, Highly Active | Antiviral Agents | Coinfection | Female | HIV Infections | Hepatitis C, Chronic | Hospital Mortality | Hospitalization | Humans | Incidence | Male | Middle Aged | Pulmonary Disease, Chronic Obstructive | Retrospective Studies | Spain | Survival Analysis
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