Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/5161
Título
Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria
Autor(es)
de la Cuesta, Fernando | Baldan-Martin, Montserrat | Moreno-Luna, Rafael | Alvarez-Llamas, Gloria | Gonzalez-Calero, Laura | Mourino-Alvarez, Laura | Sastre-Oliva, Tamara | Lopez, Juan Antonio CNIC | Vazquez, Jesus CNIC | Ruiz-Hurtado, Gema | Segura, Julian | Vivanco, Fernando | Ruilope, Luis M | Barderas, Maria G
Fecha de publicación
2017
Cita
Oncotarget. 2017; 8(9):15553-15562
Idioma
Inglés
Tipo de documento
journal article
Resumen
Despite of the great advances in anti-hypertensive therapies, many patients under Renin-Angiotensin-System (RAS) suppression develop albuminuria, which is a clear indicator of therapeutic inefficiency. Hence, indicators of vascular function are needed to assess patients' condition and help deciding future therapies. Proteomic analysis of circulating extracellular vesicles (EVs) showed two proteins, kalirin and chromodomain-helicase-DNA-binding protein 7 (CHD7), increased in albuminuric patients. A positive correlation of both with the expression of the endothelial activation marker E-selectin was found in EVs. In vitro analysis using TNFa-treated adult human endothelial cells proved their involvement in endothelial cell activation. Hence, we propose protein levels of kalirin and CHD7 in circulating EVs as novel endothelial dysfunction markers to monitor vascular condition in hypertensive patients with albuminuria.
Palabras clave
Extracellular vesicles | Proteomics | Endothelial dysfunction | Hypertension | Albuminuria | ANGIOTENSIN SYSTEM SUPPRESSION | OXIDATIVE STRESS | CELLS | MICROALBUMINURIA | DISEASE
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
- Nombre:
- KalirinAndCHD7Novel_2017_suppl2
- Tamaño:
- 4.188Mb
- Formato:
- Microsoft Excel 2007