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dc.contributor.author | de la Cuesta, Fernando | |
dc.contributor.author | Baldan-Martin, Montserrat | |
dc.contributor.author | Moreno-Luna, Rafael | |
dc.contributor.author | Alvarez-Llamas, Gloria | |
dc.contributor.author | Gonzalez-Calero, Laura | |
dc.contributor.author | Mourino-Alvarez, Laura | |
dc.contributor.author | Sastre-Oliva, Tamara | |
dc.contributor.author | Lopez, Juan Antonio | |
dc.contributor.author | Vazquez, Jesus | |
dc.contributor.author | Ruiz-Hurtado, Gema | |
dc.contributor.author | Segura, Julian | |
dc.contributor.author | Vivanco, Fernando | |
dc.contributor.author | Ruilope, Luis M | |
dc.contributor.author | Barderas, Maria G | |
dc.date.accessioned | 2017-10-20T10:33:49Z | |
dc.date.available | 2017-10-20T10:33:49Z | |
dc.date.issued | 2017 | |
dc.identifier | ISI:000396013700108 | |
dc.identifier.citation | Oncotarget. 2017; 8(9):15553-15562 | |
dc.identifier.issn | 1949-2553 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/5161 | |
dc.description.abstract | Despite of the great advances in anti-hypertensive therapies, many patients under Renin-Angiotensin-System (RAS) suppression develop albuminuria, which is a clear indicator of therapeutic inefficiency. Hence, indicators of vascular function are needed to assess patients' condition and help deciding future therapies. Proteomic analysis of circulating extracellular vesicles (EVs) showed two proteins, kalirin and chromodomain-helicase-DNA-binding protein 7 (CHD7), increased in albuminuric patients. A positive correlation of both with the expression of the endothelial activation marker E-selectin was found in EVs. In vitro analysis using TNFa-treated adult human endothelial cells proved their involvement in endothelial cell activation. Hence, we propose protein levels of kalirin and CHD7 in circulating EVs as novel endothelial dysfunction markers to monitor vascular condition in hypertensive patients with albuminuria. | |
dc.description.sponsorship | This work was supported by grants from the Instituto de Salud Carlos III (PI070537, IF08/3667-1, PI1102239, PI 14/0917, PI11/01401, PI11/02432, PI13/01873, PI13/01746, PI13/01581, PI14/01650, PI14/01841), PT13/0001/0013 ,PIE13/00051, PIE13/00045, CP09/00229, IDCSalud(3371/002), Fundacion Mutua Madrilena, Fundacion Conchita Rabago de Jimenez Diaz and FONDOS FEDER (RD06/0014/1015 ,RD12/0042/0071). These results are lined up with the Spanish initiative on the Human Proteome Project. | |
dc.language.iso | eng | |
dc.publisher | Impact Journals | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Extracellular vesicles | |
dc.subject | Proteomics | |
dc.subject | Endothelial dysfunction | |
dc.subject | Hypertension | |
dc.subject | Albuminuria | |
dc.subject | ANGIOTENSIN SYSTEM SUPPRESSION | |
dc.subject | OXIDATIVE STRESS | |
dc.subject | CELLS | |
dc.subject | MICROALBUMINURIA | |
dc.subject | DISEASE | |
dc.title | Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria | |
dc.type | journal article | |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 28152519 | |
dc.format.volume | 8 | |
dc.format.page | 15553-15562 | |
dc.identifier.doi | 10.18632/oncotarget.14948 | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | IDC Salud | |
dc.contributor.funder | Fundación Mutua Madrileña | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.description.peerreviewed | Sí | |
dc.relation.publisherversion | https://doi.org/10.18632/oncotarget.14948 | |
dc.identifier.journal | Oncotarget | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Proteómica cardiovascular | |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Proteómica / Metabolómica | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI07/0537 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/IF08/3667-1 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/02239 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/0917 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/01401 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/02432 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI13/01873 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI13/01746 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI13/01581 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/01650 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/01841 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PT13/0001/0013 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PIE13/00051 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PIE13/00045 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CP09/00229 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD06/0014/1015 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0042/0071 | es_ES |
dc.rights.accessRights | open access | es_ES |