Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20491
Título
Pathogen reduction/inactivation of products for the treatment of bleeding disorders: what are the processes and what should we say to patients?
Autor(es)
Fecha de publicación
2017-08
Cita
Di Minno Giovanni, Navarro David, Perno Carlo Federico, Canaro Hirnyk Mariana, Guertler Lutz, Ironside James W., et al. Pathogen reduction/inactivation of products for the treatment of bleeding disorders: what are the processes and what should we say to patients?. Ann Hematol. 2017 Aug;96(8):1253-1270. Epub 2017 Jun 18.
Idioma
Inglés
Tipo de documento
review article
Resumen
Patients with blood disorders (including leukaemia, platelet function disorders and coagulation factor deficiencies) or acute bleeding receive blood-derived products, such as red blood cells, platelet concentrates and plasma-derived products. Although the risk of pathogen contamination of blood products has fallen considerably over the past three decades, contamination is still a topic of concern. In order to counsel patients and obtain informed consent before transfusion, physicians are required to keep up to date with current knowledge on residual risk of pathogen transmission and methods of pathogen removal/inactivation. Here, we describe pathogens relevant to transfusion of blood products and discuss contemporary pathogen removal/inactivation procedures, as well as the potential risks associated with these products: the risk of contamination by infectious agents varies according to blood product/region, and there is a fine line between adequate inactivation and functional impairment of the product. The cost implications of implementing pathogen inactivation technology are also considered.
Palabras clave
Pathogen | Inactivation | Virus | Removal | Blood | Clotting | Bleeding disorder | Infection risk | Patient information
MESH
Blood Coagulation Disorders | Hemorrhagic Disorders | Blood Safety | Blood Transfusion | Blood-Borne Pathogens | Risk Assessment | Risk Factors | Sepsis | Disinfection | Humans
DECS
Factores de Riesgo | Humanos | Desinfección | Medición de Riesgo | Patógenos Transmitidos por la Sangre | Trastornos de la Coagulación Sanguínea | Sepsis | Transfusión Sanguínea | Trastornos Hemorrágicos | Seguridad de la Sangre
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DOI
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