Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20446
Title
Synthesis and Antimicrobial Studies of New Antibacterial Azo-Compounds Active against Staphylococcus aureus and Listeria monocytogenes
Author(s)
Date issued
2017-08
Citation
Piotto S, Concilio S, Sessa L, Diana R, Torrens Ribot G, Juan C, et al. Synthesis and Antimicrobial Studies of New Antibacterial Azo-Compounds Active against Staphylococcus aureus and Listeria monocytogenes. Molecules. 2017 Aug;22(8):1372.
Language
Inglés
Document type
research article
Abstract
Some novel (phenyl-diazenyl) phenols (4a-m) were designed and synthesized to be evaluated for their antibacterial activity. Starting from an active previously-synthesized azobenzene chosen as lead compound, we introduced some modifications and optimization of the structure, in order to improve solubility and drug conveyance. Structures of all newly-synthesized compounds were confirmed by H-1 nuclear magnetic resonance (NMR), mass spectrometry, and UV-Vis spectroscopy. Antibacterial activity of the new compounds was tested with the dilution method against the bacteria strains Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa PAO1. All the compounds were selectively active against Gram-positive bacteria. In particular, compounds 4d, 4h, and 4i showed the highest activity against S. aureus and Listeria monocytogenes, reaching remarkable MIC100 values of 4 mu g/mL and 8 mu g/mL. The relationship between antimicrobial activity and compound structure has suggested that the presence of hydroxyl groups seems to be essential for antimicrobial activity of phenolic compounds.
Subject
MESH
Listeria monocytogenes | Molecular Structure | Anti-Bacterial Agents | Microbial Sensitivity Tests | Aza Compounds | Staphylococcus aureus
DECS
Compuestos Aza | Pruebas de Sensibilidad Microbiana | Staphylococcus aureus | Listeria monocytogenes | Estructura Molecular | Antibacterianos
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