Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20446
Título
Synthesis and Antimicrobial Studies of New Antibacterial Azo-Compounds Active against Staphylococcus aureus and Listeria monocytogenes
Autor(es)
Fecha de publicación
2017-08
Cita
Piotto S, Concilio S, Sessa L, Diana R, Torrens Ribot G, Juan C, et al. Synthesis and Antimicrobial Studies of New Antibacterial Azo-Compounds Active against Staphylococcus aureus and Listeria monocytogenes. Molecules. 2017 Aug;22(8):1372.
Idioma
Inglés
Tipo de documento
research article
Resumen
Some novel (phenyl-diazenyl) phenols (4a-m) were designed and synthesized to be evaluated for their antibacterial activity. Starting from an active previously-synthesized azobenzene chosen as lead compound, we introduced some modifications and optimization of the structure, in order to improve solubility and drug conveyance. Structures of all newly-synthesized compounds were confirmed by H-1 nuclear magnetic resonance (NMR), mass spectrometry, and UV-Vis spectroscopy. Antibacterial activity of the new compounds was tested with the dilution method against the bacteria strains Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa PAO1. All the compounds were selectively active against Gram-positive bacteria. In particular, compounds 4d, 4h, and 4i showed the highest activity against S. aureus and Listeria monocytogenes, reaching remarkable MIC100 values of 4 mu g/mL and 8 mu g/mL. The relationship between antimicrobial activity and compound structure has suggested that the presence of hydroxyl groups seems to be essential for antimicrobial activity of phenolic compounds.
Palabras clave
MESH
Listeria monocytogenes | Molecular Structure | Anti-Bacterial Agents | Microbial Sensitivity Tests | Aza Compounds | Staphylococcus aureus
DECS
Compuestos Aza | Pruebas de Sensibilidad Microbiana | Staphylococcus aureus | Listeria monocytogenes | Estructura Molecular | Antibacterianos
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DOI
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