Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20425
Título
Improvement of Antioxidant Defences and Mood Status by Oral GABA Tea Administration in a Mouse Model of Post-Stroke Depression
Autor(es)
Fecha de publicación
2017-05
Cita
Daglia M, Di Lorenzo A, Nabavi Seyed F, Sureda Gomila A, Khanjani S, Moghaddam Akbar H, et al. Improvement of Antioxidant Defences and Mood Status by Oral GABA Tea Administration in a Mouse Model of Post-Stroke Depression. Nutrients. 2017 May;9(5):446.
Idioma
Inglés
Tipo de documento
research article
Resumen
Green GABA (GGABA) and Oolong GABA (OGABA) teas are relatively new varieties of tea, whose chemical composition and functional properties are largely under-studied, despite their promising health capacities. Post stroke depression (PSD) is a complication of stroke with high clinical relevance, yielding increasing mortality and morbidity rates, and a lower response to common therapies and rehabilitation. Methods: Two chemically characterized commercial samples of GGABA and OGABA were investigated for effects on mood following oral administration using a mouse model of PSD, through common validated tests including the Despair Swimming Test and Tail Suspension Test. Moreover, the antioxidant activity of GGABA and OGABA was evaluated by determining the levels of lipid peroxidation products and the activity of antioxidant enzymes in the mouse brain in vivo. Results: GGABA and OGABA attenuated depressed mood by influencing behavioral parameters linked to depression. GGABA was more active than OGABA in this study, and this effect may be likely due to a higher content of polyphenolic substances and amino acids in GGABA compared to OGABA. GGABA also exerted a greater antioxidant activity. Conclusions: Our data suggests that GABA tea is a promising candidate that can be used as an adjuvant in the management of PSD.
Palabras clave
MESH
Mice, Inbred BALB C | Polyphenols | Affect | Plant Extracts | Glutamine | Depression | Stroke | Glutamates | Disease Models, Animal | gamma-Aminobutyric Acid | Male | Animals | Lipid Peroxidation | Reproducibility of Results | Tea | Glutamic Acid | Mice
DECS
Animales | Ácido Glutámico | T� | Accidente Cerebrovascular | Reproducibilidad de los Resultados | Peroxidación de Lípido | Modelos Animales de Enfermedad | Ácido gamma-Aminobut�rico | Masculino | Extractos Vegetales | Glutamina | Glutamatos | Polifenoles | Depresión | Ratones | Afecto | Ratones Endog�micos BALB C
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