Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20400
Title
Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study
Author(s)
Downer, Mary Kathryn | Martinez-Gonzalez, Miguel A | Gea, Alfredo | Stampfer, Meir | Warnberg, Julia | Ruiz-Canela, Miguel | Salas-Salvado, Jordi | Corella, Dolores | Ros, Emilio | Fito, Montserrat | Estruch, Ramon | Aros, Fernando | | Lapetra, Jose | Serra-Majem, Lluis | Bullo, Monica | Sorli, Jose V | Munoz, Miguel A | Garcia-Rodriguez, Antonio | Gutierrez-Bedmar, Mario | Gomez-Gracia, Enrique | PREDIMED Study Investigators
Date issued
2017-01-05
Citation
Downer MK, Martinez-Gonzalez MA, Gea A, Stampfer M, Warnberg J, Ruiz-Canela M, et al. Mercury exposure and risk of cardiovascular disease: a nested case-control study in the PREDIMED (PREvention with MEDiterranean Diet) study. BMC Cardiovasc Disord. 2017 Jan 05;17:9.
Language
Inglés
Document type
research article
Abstract
Background: Substantial evidence suggests that consuming 1-2 servings of fish per week, particularly oily fish (e.g., salmon, herring, sardines) is beneficial for cardiovascular health due to its high n-3 polyunsaturated fatty acid content. However, there is some concern that the mercury content in fish may increase cardiovascular disease risk, but this relationship remains unclear. Methods: The PREDIMED trial included 7477 participants who were at high risk for cardiovascular disease at baseline. In this study, we evaluated associations between mercury exposure, fish consumption and cardiovascular disease. We randomly selected 147 of the 288 cases diagnosed with cardiovascular disease during follow-up and matched them on age and sex to 267 controls. Instrumental neutron activation analysis was used to assess toenail mercury concentration. In-person interviews, medical record reviews and validated questionnaires were used to assess fish consumption and other covariates. Information was collected at baseline and updated yearly during follow-up. We used conditional logistic regression to evaluate associations in the total nested case-control study, and unconditional logistic regression for population subsets. Results: Mean (+/- SD) toenail mercury concentrations (mu g per gram) did not significantly differ between cases (0.63 (+/- 0.53)) and controls (0.67 (+/- 0.49)). Mercury concentration was not associated with cardiovascular disease in any analysis, and neither was fish consumption or n-3 fatty acids. The fully-adjusted relative risks for the highest versus lowest quartile of mercury concentration were 0.71 (95% Confidence Interval [CI], 0.34, 1.14; p(trend) = 0.37) for the nested case-control study, 0.74 (95% CI, 0.32, 1.76; p(trend) = 0.43) within the Mediterranean diet intervention group, and 0.50 (95% CI, 0.13, 1.96; p(trend) = 0.41) within the control arm of the trial. Associations remained null when mercury was jointly assessed with fish consumption at baseline and during follow-up. Results were similar in different sensitivity analyses. Conclusions: We found no evidence that mercury exposure from regular fish consumption increases cardiovascular disease risk in a population of Spanish adults with high cardiovascular disease risk and high fish consumption. This implies that the mercury content in fish does not detract from the already established cardiovascular benefits of fish consumption.
Subject
MESH
Aged, 80 and over | Aged | Risk Assessment | Humans | Methylmercury Compounds | Protective Factors | Male | Multivariate Analysis | Time Factors | Female | Nails | Risk Factors | Body Burden | Cardiovascular Diseases | Case-Control Studies | Spain | Food Contamination | Recommended Dietary Allowances | Middle Aged | Prospective Studies | Seafood | Diet, Mediterranean | Odds Ratio | Water Pollutants, Chemical | Logistic Models
DECS
Dieta Mediterránea | Modelos Logísticos | Oportunidad Relativa | Alimentos Marinos | Contaminantes Químicos del Agua | Femenino | Uvas | Masculino | Factores Protectores | Persona de Mediana Edad | Estudios Prospectivos | Medición de Riesgo | Enfermedades Cardiovasculares | Contaminación de Alimentos | Carga Corporal (Radioterapia) | Ingesta Diaria Recomendada | Factores de Tiempo | Análisis Multivariante | Factores de Riesgo | Humanos | Compuestos de Metilmercurio | Anciano | Anciano de 80 o más Años | España | Estudios de Casos y Controles
Online version
DOI
Collections
- Investigación > IIS > IdisBa - Instituto de Investigación Sanitaria Illes Balears (Baleares)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > IIS > IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
- Investigación > IIS > IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
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