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dc.contributor.author | Gallardo, David | |
dc.contributor.author | Bosch-Vizcaya, Anna | |
dc.contributor.author | Rodriguez-Romanos, Rocio | |
dc.contributor.author | Santos, Nazly | |
dc.contributor.author | Buno, Ismael | |
dc.contributor.author | de la Cámara, Rafael | |
dc.contributor.author | Brunet, Salut | |
dc.contributor.author | Jimenez-Velasco, Antonio | |
dc.contributor.author | Gonzalez, Marcos | |
dc.contributor.author | Nieto, Jose B | |
dc.contributor.author | Martinez-Laperche, Carolina | |
dc.contributor.author | Vallejo, Carlos | |
dc.contributor.author | Ferra, Christelle | |
dc.contributor.author | Sampol Mayol, Antonia | |
dc.contributor.author | Lopez-Jimenez, Javier | |
dc.contributor.author | Perez-Simon, Jose A | |
dc.contributor.author | Martinez, Carmen | |
dc.contributor.author | Diez, Jose-Luis | |
dc.contributor.author | Spanish Hematopoietic Transplant | |
dc.date.accessioned | 2024-07-11T09:07:22Z | |
dc.date.available | 2024-07-11T09:07:22Z | |
dc.date.issued | 2017-12 | |
dc.identifier.citation | Gallardo D, Bosch-Vizcaya A, Rodriguez-Romanos R, Santos N, Buno I, De la Camara R, et al. Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches. Biol Blood Marrow Transplant. 2017 Dec;23(12):2042-7. Epub 2017 Aug 4. | en |
dc.identifier.issn | 1083-8791 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/17289 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20386 | |
dc.description.abstract | Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of acute GVHD. We explored the effect of the donor's CTLA-4 genotype in the incidence of acute GVHD associated with HA-1, HA-8, or H-Y miHA mismatches in a large cohort of 1295 patients receiving an allogeneic transplant from an HLA-identical sibling donor. The incidence of acute GVHD was higher if the donor and recipient were mismatched for HA-1, HA-8, or H-Y, but only when the donor had the CTLA-4 rs231775 AA genotype (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.75; P=.005; HR, 2.11, 95% CI, 1.06 to 4.18; P=.033; and HR, 1.50; 95% CI, 1.05 to 2.15; P=.025, respectively). In contrast, this increased risk of developing acute GVHD was not found when the donor presented the CTLA-4 rs231775 AG or GG genotypes. We conclude that the immune response to specific miHA mismatches is modulated by the CTLA-4 genotype of the donor. | en |
dc.description.sponsorship | Supported in part by grants PI11/01690 and PI14/01646 from the Fondo de investigaciones sanitarias, Institute de Salud Carlos III, FEDER (Fondo Europeo de desarrollo regional), and grant MTV3/120210 from the Fundacio la Marato de TV3. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Elsevier | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | CTLA-4 | |
dc.subject | Minor histocompatibility antigens | |
dc.subject | Graft-versus-host disease | |
dc.subject | Allogeneic transplantation | |
dc.subject.mesh | Child | * |
dc.subject.mesh | Genotype | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | CTLA-4 Antigen | * |
dc.subject.mesh | Young Adult | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Histocompatibility | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Immunity | * |
dc.subject.mesh | Child, Preschool | * |
dc.subject.mesh | Adolescent | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Infant | * |
dc.subject.mesh | Graft vs Host Disease | * |
dc.subject.mesh | Tissue Donors | * |
dc.subject.mesh | Minor Histocompatibility Antigens | * |
dc.title | Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches | en |
dc.type | research article | en |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.identifier.pubmedID | 28827064 | es_ES |
dc.format.volume | 23 | es_ES |
dc.format.number | 12 | es_ES |
dc.format.page | 2042-2047 | es_ES |
dc.identifier.doi | 10.1016/j.bbmt.2017.08.003 | |
dc.identifier.e-issn | 1523-6536 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1016/j.bbmt.2017.08.003 | en |
dc.identifier.journal | Biology of Blood and Marrow Transplantation | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Antígenos de Histocompatibilidad Menor | * |
dc.subject.decs | Enfermedad Injerto contra Huésped | * |
dc.subject.decs | Donantes de Tejidos | * |
dc.subject.decs | Lactante | * |
dc.subject.decs | Adolescente | * |
dc.subject.decs | Inmunidad | * |
dc.subject.decs | Preescolar | * |
dc.subject.decs | Histocompatibilidad | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Adulto Joven | * |
dc.subject.decs | Anciano | * |
dc.subject.decs | Genotipo | * |
dc.subject.decs | Niño | * |
dc.subject.decs | Adulto | * |
dc.subject.decs | Antígeno CTLA-4 | * |
dc.identifier.scopus | 2-s2.0-85028624003 | |
dc.identifier.wos | 418309000005 | |
dc.identifier.pui | L618107562 |
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