Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20386
Título
Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches
Autor(es)
Gallardo, David | Bosch-Vizcaya, Anna | Rodriguez-Romanos, Rocio | Santos, Nazly | Buno, Ismael | de la Cámara, Rafael | Brunet, Salut | Jimenez-Velasco, Antonio | Gonzalez, Marcos | Nieto, Jose B | Martinez-Laperche, Carolina | Vallejo, Carlos | Ferra, Christelle | Sampol Mayol, Antonia | Lopez-Jimenez, Javier | Perez-Simon, Jose A | Martinez, Carmen | Diez, Jose-Luis | Spanish Hematopoietic Transplant
Fecha de publicación
2017-12
Cita
Gallardo D, Bosch-Vizcaya A, Rodriguez-Romanos R, Santos N, Buno I, De la Camara R, et al. Donor CTLA-4 Genotype Modulates the Immune Response to Minor Histocompatibility Antigen Mismatches. Biol Blood Marrow Transplant. 2017 Dec;23(12):2042-7. Epub 2017 Aug 4.
Idioma
Inglés
Tipo de documento
research article
Resumen
Minor histocompatibility antigen (miHA) mismatches have been related to graft-versus-host disease (GVHD) after allogeneic stem cell transplantation, but this association remains controversial due to the lack of consistency in the results obtained by different groups. The CTLA-4 genotype of the donor has been reported to be relevant in the appearance of acute GVHD. We explored the effect of the donor's CTLA-4 genotype in the incidence of acute GVHD associated with HA-1, HA-8, or H-Y miHA mismatches in a large cohort of 1295 patients receiving an allogeneic transplant from an HLA-identical sibling donor. The incidence of acute GVHD was higher if the donor and recipient were mismatched for HA-1, HA-8, or H-Y, but only when the donor had the CTLA-4 rs231775 AA genotype (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.27 to 3.75; P=.005; HR, 2.11, 95% CI, 1.06 to 4.18; P=.033; and HR, 1.50; 95% CI, 1.05 to 2.15; P=.025, respectively). In contrast, this increased risk of developing acute GVHD was not found when the donor presented the CTLA-4 rs231775 AG or GG genotypes. We conclude that the immune response to specific miHA mismatches is modulated by the CTLA-4 genotype of the donor.
Palabras clave
MESH
Child | Genotype | Aged | CTLA-4 Antigen | Young Adult | Adult | Histocompatibility | Humans | Immunity | Child, Preschool | Adolescent | Middle Aged | Infant | Graft vs Host Disease | Tissue Donors | Minor Histocompatibility Antigens
DECS
Antígenos de Histocompatibilidad Menor | Enfermedad Injerto contra Huésped | Donantes de Tejidos | Lactante | Adolescente | Inmunidad | Preescolar | Histocompatibilidad | Humanos | Persona de Mediana Edad | Adulto Joven | Anciano | Genotipo | Niño | Adulto | Antígeno CTLA-4
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DOI
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