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Título
Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea
Autor(es)
Fecha de publicación
2017-05
Cita
Serrano-Pariente J, Plaza V, Soriano JB, Mayos M, Lopez-Vina A, Picado C, et al. Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea. Allergy. 2017 May;72(5):802-12. Epub 2016 Nov 3.
Idioma
Inglés
Tipo de documento
research article
Resumen
BackgroundContinuous positive airway pressure (CPAP) in asthma patients with concomitant obstructive sleep apnea syndrome (OSAS) seems to have a favorable impact on asthma, but data are inconsistent due to methodological limitations of previous studies. MethodsProspective, multicenter study. We examined asthma outcomes after 6 months of CPAP in 99 adult asthma patients (mean age 57 years) with OSAS (respiratory disturbance index 20). Asthma control and quality of life were assessed with the Asthma Control Questionnaire (ACQ) and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ), respectively. Data were analyzed by intention-to-treat basis. ResultsThe mean SD score of the ACQ decreased from 1.39 +/- 0.91 at baseline to 1.0 +/- 0.78 at 6 months (P = 0.003), the percentage of patients with uncontrolled asthma from 41.4% to 17.2% (P = 0.006), and the percentage of patients with asthma attacks in the 6 months before and after treatment from 35.4% to 17.2% (P = 0.015). The score of the mAQLQ increased from 5.12 +/- 1.38 to 5.63 +/- 1.17 (P = 0.009). There were also significant improvements in symptoms of gastroesophageal reflux and rhinitis, bronchial reversibility, and exhaled nitric oxide values (all P < 0.05). No significant changes were observed in drug therapy for asthma or their comorbidities nor in the patients' weight. ConclusionsAsthma control (both actual and future risk), quality of life, and lung function improved after starting continuous positive airway pressure in asthmatics with moderate to severe obstructive sleep apnea syndrome.
Palabras clave
Asthma | Bronchial hyperreactivity | Continuous positive airway pressure | Obstructive sleep apnea syndrome | Quality of life
MESH
Asthma | Continuous Positive Airway Pressure | Disease Progression | Aged | Adult | Sleep Apnea, Obstructive | Humans | Middle Aged | Patient Outcome Assessment | Respiratory Function Tests | Male | Quality of Life | Severity of Illness Index | Prospective Studies | Female | Risk Factors | Treatment Outcome
DECS
Resultado del Tratamiento | Femenino | Presión de las Vías Aéreas Positiva Contínua | Masculino | Apnea Obstructiva del Sueño | Factores de Riesgo | Humanos | Persona de Mediana Edad | Calidad de Vida | Pruebas de Función Respiratoria | Evaluación del Resultado de la Atención al Paciente | Estudios Prospectivos | Anciano | Asma | Índice de Severidad de la Enfermedad | Progresión de la Enfermedad | Adulto
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