Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20314
Título
Gut epithelial barrier markers in patients with obstructive sleep apnea
Autor(es)
Fecha de publicación
2016-10
Cita
Barcelo Bennasar Antonia, Esquinas Cristina, Robles Juan, Pierola Javier, De La Peña Bravo Mónica, Aguilar Irene, et al. Gut epithelial barrier markers in patients with obstructive sleep apnea. Sleep Med. 2016 Oct;26:12-15. Epub 2016 Sep 28.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. Results: Compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables. Conclusions: The results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA.
Palabras clave
MESH
Metabolic Syndrome | Case-Control Studies | Adult | Intestinal Absorption | Sleep Apnea, Obstructive | Cholera Toxin | Humans | Alanine Transaminase | Intestinal Mucosa | Middle Aged | Non-alcoholic Fatty Liver Disease | Obesity | Male | Biomarkers | Female | Fatty Acid-Binding Proteins | Waist Circumference | Retrospective Studies
DECS
Biomarcadores | Síndrome Metabólico | Femenino | Enfermedad del Hígado Graso no Alcohólico | Masculino | Circunferencia de la Cintura | Toxina del Cólera | Apnea Obstructiva del Sueño | Humanos | Persona de Mediana Edad | Obesidad | Alanina Transaminasa | Mucosa Intestinal | Proteínas de Unión a ácidos Grasos | Estudios Retrospectivos | Adulto | Absorción Intestinal | Estudios de Casos y Controles
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