Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20304
Title
Cost-effectiveness analysis of quadrivalent influenza vaccine in Spain
Author(s)
Date issued
2016
Citation
Garcia A, Ortiz De Lejarazu R, Reina J, Callejo D, Cuervo J, Morano Larragueta R. Cost-effectiveness analysis of quadrivalent influenza vaccine in Spain. Human Vaccines Immunother. 2016;12(9):2269-77. Epub 2016 May 16.
Language
Inglés
Document type
research article
Abstract
Influenza has a major impact on healthcare systems and society, but can be prevented using vaccination. The World Health Organization (WHO) currently recommends that influenza vaccines should include at least two virus A and one virus B lineage (trivalent vaccine; TIV). A new quadrivalent vaccine (QIV), which includes an additional B virus strain, received regulatory approval and is now recommended by several countries. The present study estimates the cost-effectiveness of replacing TIVs with QIV for risk groups and elderly population in Spain. A static, lifetime, multi-cohort Markov model with a one-year cycle time was adapted to assess the costs and health outcomes associated with a switch from TIV to QIV. The model followed a cohort vaccinated each year according to health authority recommendations, for the duration of their lives. National epidemiological data allowed the determination of whether the B strain included in TIVs matched the circulating one. Societal perspective was considered, costs and outcomes were discounted at 3% and one-way and probabilistic sensitivity analyses were performed. Compared to TIVs, QIV reduced more influenza cases and influenza-related complications and deaths during periods of B-mismatch strains in the TIV. The incremental cost-effectiveness ratio (ICER) was 8,748Euro/quality-adjusted life year (QALY). One-way sensitivity analysis showed mismatch with the B lineage included in the TIV was the main driver for ICER. Probabilistic sensitivity analysis shows ICER below 30,000Euro/QALY in 96% of simulations. Replacing TIVs with QIV in Spain could improve influenza prevention by avoiding B virus mismatch and provide a cost-effective healthcare intervention.
Subject
Costs and cost analysis | Cost-effectiveness analysis | Human | Healthcare costs | Influenza | Influenza B virus | Influenza vaccines | QIV | Vaccines
MESH
Child | Aged, 80 and over | Aged | Young Adult | Cost of Illness | Spain | Adult | Humans | Child, Preschool | Adolescent | Cost-Benefit Analysis | Middle Aged | Infant | Pregnancy | Influenza Vaccines | Male | Influenza, Human | Female
DECS
Femenino | Lactante | Análisis Costo-Beneficio | Gripe Humana | Adolescente | Vacunas contra la Influenza | Masculino | Preescolar | Humanos | Persona de Mediana Edad | Adulto Joven | Embarazo | Anciano | Anciano de 80 o más Años | Niño | Costo de Enfermedad | Adulto | España
Online version
DOI
Collections
Full text access