Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20268
Title
Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial
Author(s)
Date issued
2016-06-08
Citation
Roca M, Kohls E, Gili M, Watkins Ed, Owens M, Hegerl U, et al. Prevention of depression through nutritional strategies in high-risk persons: rationale and design of the MooDFOOD prevention trial. BMC Psychiatry. 2016 Jun 08;16:192.
Language
Inglés
Document type
research article
Abstract
Background: Obesity and depression are two prevalent conditions that are costly to individuals and society. The bidirectional association of obesity with depression, in which unhealthy dietary patterns may play an important role, has been well established. Few experimental studies have been conducted to investigate whether supplementing specific nutrients or improving diet and food-related behaviors can prevent depression in overweight persons. Method/Design: The MooDFOOD prevention trial examines the feasibility and effectiveness of two different nutritional strategies [multi-nutrient supplementation and food-related behavioral change therapy (FBC)] to prevent depression in individuals who are overweight and have elevated depressive symptoms but who are not currently or in the last 6 months meeting criteria for an episode of major depressive disorder (MDD). The randomized controlled prevention trial has a two-by-two factorial design: participants are randomized to daily multi-nutrient supplement (omega-3 fatty acids, calcium, selenium, B-11 vitamin and D-3 vitamin) versus placebo, and/or FBC therapy sessions versus usual care. Interventions last 12 months. In total 1000 participants aged 18-75 years with body mass index between 25-40 kg/m(2) and with a Patient Health Questionnaire-9 score >= 5 will be recruited at four study sites in four European countries. Baseline and follow-up assessments take place at 0, 3, 6, and 12 months. Primary endpoint is the onset of an episode of MDD, assessed according to DSM-IV based criteria using the MINI 5. 0 interview. Depressive symptoms, anxiety, food and eating behavior, physical activity and health related quality of life are secondary outcomes. During the intervention, compliance, adverse events and potentially mediating variables are carefully monitored. Discussion: The trial aims to provide a better understanding of the causal role of specific nutrients, overall diet, and food-related behavior change with respect to the incidence of MDD episodes. This knowledge will be used to develop and disseminate innovative evidence-based, feasible, and effective nutritional public health strategies for the prevention of clinical depression.
Subject
Depression | Overweight | Multi-nutrient supplements | Diet | Food behavioral activation | Food behavior | Prevention | Randomized controlled trial
MESH
Aged | Clinical Protocols | Young Adult | Adult | Humans | Feasibility Studies | Research Design | Diet | Male | Europe | Female | Risk Factors | Anxiety | Depressive Disorder, Major | Feeding Behavior | Depression | Adolescent | Behavior Therapy | Middle Aged | Obesity | Diet Therapy | Quality of Life | Vitamins | Overweight | Dietary Supplements
DECS
Femenino | Europa (Continente) | Dieta | Vitaminas | Adolescente | Estudios de Factibilidad | Masculino | Conducta Alimentaria | Dietoterapia | Trastorno Depresivo Mayor | Persona de Mediana Edad | Obesidad | Calidad de Vida | Terapia Conductista | Depresión | Ansiedad | Suplementos Dietéticos | Sobrepeso | Factores de Riesgo | Humanos | Proyectos de Investigación | Protocolos Clínicos | Adulto Joven | Anciano | Adulto
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