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dc.contributor.author | Zheng, Yan | |
dc.contributor.author | Hu, Frank B | |
dc.contributor.author | Ruiz-Canela, Miguel | |
dc.contributor.author | Clish, Clary B | |
dc.contributor.author | Dennis, Courtney | |
dc.contributor.author | Salas-Salvado, Jordi | |
dc.contributor.author | Hruby, Adela | |
dc.contributor.author | Liang, Liming | |
dc.contributor.author | Toledo, Estefanía | |
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | Fito, Montserrat | |
dc.contributor.author | Gomez-Gracia, Enrique | |
dc.contributor.author | Aros, Fernando | |
dc.contributor.author | ||
dc.contributor.author | Lapetra, Jose | |
dc.contributor.author | Serra-Majem, Lluis | |
dc.contributor.author | Estruch, Ramon | |
dc.contributor.author | Martinez-Gonzalez, Miguel A | |
dc.date.accessioned | 2024-07-09T09:13:03Z | |
dc.date.available | 2024-07-09T09:13:03Z | |
dc.date.issued | 2016-09 | |
dc.identifier.citation | Zheng Y, Hu FB, Ruiz-Canela M, Clish CB, Dennis C, Salas-Salvado J, et al. Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvencion con DIeta MEDiterranea (PREDIMED) Trial. J Am Heart Assoc. 2016 Sep;5(9):e003755. | en |
dc.identifier.issn | 2047-9980 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/17180 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20240 | |
dc.description.abstract | Background: Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD). Methods and Results: Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age 68 years; 46% male) from the PREvencion con DIeta MEDiterranea (PREDIMED) randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of follow-up, there were 229 incident CVD events (nonfatal stroke, nonfatal myocardial infarction, or CVD death). In fully adjusted models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16% to 76%) and 81% (39% to 137%) increased risk of composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6% to 40%) and 44% (25% to 58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both P-linear trend <= 0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to the control diet; the intervention effects were not significant when baseline glutamate was low (P-interaction=0.02). No significant effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was apparent. Conclusions: Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels. | en |
dc.description.sponsorship | This work was supported by the National Institutes of Health, 1R01HL118264. The PREDIMED trial was supported by the official funding agency for Biomedical Research of the Spanish Government, Instituto de Salud Carlos III, through grants provided to research networks specifically developed for the trial: RTIC G03/140 (Period 2003-2006, Coordinator: R. Estruch, MD, PhD), and RTIC RD 06/0045 (Period 2007-2013, Coordinator: M. A. Martinez-Gonzalez, MD, PhD). We also acknowledge the grants from Centro Nacional de Investigaciones Cardiovasculares CNIC06/2007, Fondo de Investigacion Sanitaria-Fondo Europeo de Desarrollo Regional (PI04-2239, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI08/1259, PI10/01407, PI11/01647, PI11/01791), and Consejeria de Salud de la Junta de Andalucia (PI0105/2007). Ministerio de Ciencia e Innovacion (AGL-2009-13906-C02, AGL2010-22319-C03), Fundacion Mapfre 2010, Consejeria de Salud de la Junta de Andalucia (PI0105/2007), Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion-EU FEDER (PI 2007/050), Public Health Division of the Department of Health of the Autonomous Government of Catalonia and Generalitat Valenciana (ACOMP06109, GVA-COMP2010-181, GVACOMP2011-151, CS2010-AP-111, CS2011-AP-042, AP-042/11 and BEST11-263) and Ministerio de Economia (PI07-0954, CNIC-06, AGL2010-22319-C03-03, PI11/02505). CIBEROBN is an initiative of ISCIII, Spain. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Wiley | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Cardiovascular disease | |
dc.subject | Diet | |
dc.subject | Dietary clinical trial | |
dc.subject | Epidemiology | |
dc.subject | Glutamate | |
dc.subject | Glutamine | |
dc.subject | Incidence | |
dc.subject | Stroke | |
dc.subject.mesh | Cardiovascular Diseases | * |
dc.subject.mesh | Diabetes Mellitus, Type 2 | * |
dc.subject.mesh | Aged, 80 and over | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Randomized Controlled Trials as Topic | * |
dc.subject.mesh | Spain | * |
dc.subject.mesh | Glutamine | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Smoking | * |
dc.subject.mesh | Hypertension | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Stroke | * |
dc.subject.mesh | Myocardial Infarction | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Cholesterol, LDL | * |
dc.subject.mesh | Cholesterol, HDL | * |
dc.subject.mesh | Dyslipidemias | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Risk Factors | * |
dc.subject.mesh | Proportional Hazards Models | * |
dc.subject.mesh | Diet, Mediterranean | * |
dc.subject.mesh | Tobacco Smoking | * |
dc.subject.mesh | Glutamic Acid | * |
dc.subject.mesh | Incidence | * |
dc.title | Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvencion con DIeta MEDiterranea (PREDIMED) Trial | en |
dc.type | research article | en |
dc.rights.license | Attribution-NonCommercial 4.0 International | * |
dc.identifier.pubmedID | 27633391 | es_ES |
dc.format.volume | 5 | es_ES |
dc.format.number | 9 | es_ES |
dc.format.page | e003755 | es_ES |
dc.identifier.doi | 10.1161/JAHA.116.003755 | |
dc.relation.publisherversion | https://dx.doi.org/10.1161/JAHA.116.003755 | en |
dc.identifier.journal | Journal of the American Heart Association | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Dieta Mediterránea | * |
dc.subject.decs | Incidencia | * |
dc.subject.decs | Modelos de Riesgos Proporcionales | * |
dc.subject.decs | Ácido Glutámico | * |
dc.subject.decs | Accidente Cerebrovascular | * |
dc.subject.decs | LDL-Colesterol | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Infarto del Miocardio | * |
dc.subject.decs | Fumar Tabaco | * |
dc.subject.decs | HDL-Colesterol | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Glutamina | * |
dc.subject.decs | Hipertensión | * |
dc.subject.decs | Fumar | * |
dc.subject.decs | Factores de Riesgo | * |
dc.subject.decs | Dislipidemias | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Anciano | * |
dc.subject.decs | Anciano de 80 o más Años | * |
dc.subject.decs | Diabetes Mellitus Tipo 2 | * |
dc.subject.decs | Enfermedades Cardiovasculares | * |
dc.subject.decs | Ensayos Clínicos Controlados Aleatorios como Asunto | * |
dc.subject.decs | España | * |
dc.identifier.scopus | 2-s2.0-85016728658 | |
dc.identifier.wos | 386716900037 | |
dc.identifier.pui | L618953066 |
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