Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20240
Title
Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvencion con DIeta MEDiterranea (PREDIMED) Trial
Author(s)
Zheng, Yan | Hu, Frank B | Ruiz-Canela, Miguel | Clish, Clary B | Dennis, Courtney | Salas-Salvado, Jordi | Hruby, Adela | Liang, Liming | Toledo, Estefanía | Corella, Dolores | Ros, Emilio | Fito, Montserrat | Gomez-Gracia, Enrique | Aros, Fernando | | Lapetra, Jose | Serra-Majem, Lluis | Estruch, Ramon | Martinez-Gonzalez, Miguel A
Date issued
2016-09
Citation
Zheng Y, Hu FB, Ruiz-Canela M, Clish CB, Dennis C, Salas-Salvado J, et al. Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvencion con DIeta MEDiterranea (PREDIMED) Trial. J Am Heart Assoc. 2016 Sep;5(9):e003755.
Language
Inglés
Document type
research article
Abstract
Background: Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD). Methods and Results: Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age 68 years; 46% male) from the PREvencion con DIeta MEDiterranea (PREDIMED) randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of follow-up, there were 229 incident CVD events (nonfatal stroke, nonfatal myocardial infarction, or CVD death). In fully adjusted models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16% to 76%) and 81% (39% to 137%) increased risk of composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6% to 40%) and 44% (25% to 58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both P-linear trend <= 0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to the control diet; the intervention effects were not significant when baseline glutamate was low (P-interaction=0.02). No significant effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was apparent. Conclusions: Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels.
Subject
Cardiovascular disease | Diet | Dietary clinical trial | Epidemiology | Glutamate | Glutamine | Incidence | Stroke
MESH
Cardiovascular Diseases | Diabetes Mellitus, Type 2 | Aged, 80 and over | Aged | Randomized Controlled Trials as Topic | Spain | Glutamine | Humans | Smoking | Hypertension | Middle Aged | Stroke | Myocardial Infarction | Male | Cholesterol, LDL | Cholesterol, HDL | Dyslipidemias | Female | Risk Factors | Proportional Hazards Models | Diet, Mediterranean | Tobacco Smoking | Glutamic Acid | Incidence
DECS
Dieta Mediterránea | Incidencia | Modelos de Riesgos Proporcionales | Ácido Glutámico | Accidente Cerebrovascular | LDL-Colesterol | Femenino | Infarto del Miocardio | Fumar Tabaco | HDL-Colesterol | Masculino | Glutamina | Hipertensión | Fumar | Factores de Riesgo | Dislipidemias | Humanos | Persona de Mediana Edad | Anciano | Anciano de 80 o más Años | Diabetes Mellitus Tipo 2 | Enfermedades Cardiovasculares | Ensayos Clínicos Controlados Aleatorios como Asunto | España
Online version
DOI
Collections
- Investigación > IIS > IdisBa - Instituto de Investigación Sanitaria Illes Balears (Baleares)
- Investigación > IIS > IMIM - Hospital del Mar Research Institute-Barcelona (Cataluña)
- Investigación > IIS > IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
- Investigación > IIS > IdiSNA - Instituto de Investigación Sanitaria de Navarra (Navarra)
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