Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20232
Title
Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015
Author(s)
Bousquet, J | Anto, JM | Akdis, M | Auffray, C | Keil, T | Momas, I | Postma, DS | Valenta, R | Wickman, M | Cambon-Thomsen, A | Haahtela, Tari | Lambrecht, BN | Lodrup Carlsen, KC | Koppelman, G. H | Sunyer, J | Zuberbier, T | Annesi-Maesano, I | Arno, A | Bindslev-Jensen, C | De Carlo, G | Forastiere, Francesco | Heinrich, Joachim | Kowalski, ML | Maier, D | Melen, E | Palkonen, S | Smit, HA | Standl, M | Wright, J | Asarnoj, A | Benet, M | Ballardini, N | Garcia-Aymerich, J | Gehring, U | Guerra, S | Hohman, C | Kull, I | Lupinek, C | Pinart, M | Skrindo, I | Westman, M | Smagghe, D | Akdis, C | Albang, R | Anastasova, V | Anderson, N | Bachert, C | Ballereau, S | Ballester, F | Basagana, X | Bedbrook, A | Bergstrom, A | von Berg, A | Brunekreef, B | Burte, E | Carlsen, KH | Chatzi, L | Coquet, JM | Curin, M | Demoly, P | Eller, E | Fantini, Maria Pia | Gerhard, B | Hammad, H | von Hertzen, L | Hovland, V | Jacquemin, B | Just, J | Keller, T | Kerkhof, M | Kiss, R | Kogevinas, M | Koletzko, S | Lau, S | Lehmann, I | Lemonnier, N | McEachan, R | Makela, M | Mestres, J | Minina, E | Mowinckel, P | Nadif, R | Nawijn, M | Oddie, S | Pellet, J | Pin, I | Porta, D | Ranciere, F | Rial-Sebbag, A | Saeys, Y | Schuijs, MJ | Siroux, V | Tischer, CG | Torrent Quetglas, Maties | Varraso, R | De Vocht, J | Wenger, K | Wieser, S | Xu, C
Date issued
2016-11
Citation
Bousquet J, Anto JM, Akdis M, Auffray C, Keil T, Momas I, et al. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story Mechanisms of the Development of ALLergy; EUFP7-CP-IP; Project No: 261357; 2010-2015. Allergy. 2016 Nov;71(11):1513-25. Epub 2016 Aug 23.
Language
Inglés
Document type
review article
Abstract
MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.
Subject
MESH
Prognosis | World Health Organization | Precision Medicine | European Union | Health Policy | Hypersensitivity | Immunoglobulin E | Humans | Inventions | Systems Biology | Disease Management | Immunization
DECS
Manejo de la Enfermedad | Política de Salud | Hipersensibilidad | Inmunización | Biología de Sistemas | Humanos | Pronóstico | Unión Europea | Organización Mundial de la Salud | Medicina de Precisión | Inmunoglobulina E | Invenciones
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