Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20176
Title
Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?
Author(s)
Eguaras, Sonia | Toledo, Estefanía | Buil-Cosiales, P | Salas-Salvado, J | Corella, Dolores | Gutierrez-Bedmar, M | Santos-Lozano, J. M | Aros, F | Fiol Sala, Miquel | Fito Manteca, Maria Concepcion | Ros, E | Serra-Majem, L | Pinto, X | Martinez, JA | Sorli, JV | Munoz, MA | Basora, J | Estruch, Ramon | Martinez-Gonzalez, MA | PREDIMED Investigators
Date issued
2015-06
Citation
Eguaras S., Toledo E., Buil-Cosiales P., Salas-Salvado J., Corella D., Gutierrez-Bedmar M., et al. Does the Mediterranean diet counteract the adverse effects of abdominal adiposity?. Nutr Metab Carbiovasc Dis. 2015 Jun;25(6):569-574. Epub 2015 Mar 11.
Language
Inglés
Document type
research article
Abstract
Background and aim: We tested the hypothesis that an intervention with a Mediterranean diet (MeDiet) could mitigate the well-known harmful effects of abdominal obesity on cardiovascular health. Methods and results: We assessed the relationship between baseline waist-to-height ratio (WHtR) and major cardiovascular events during a median follow-up of 4.8 years in the Prevention with Mediterranean Diet (PREDIMED) randomized primary prevention trial, which tested a MeDiet against a control diet (advice on a low-fat diet). We also examined whether the MeDiet intervention was able to counteract the detrimental cardiovascular effects of an increased WHtR. The trial included 7447 participants (55-80 years old, 57% women) at high cardiovascular risk but free of cardiovascular disease (CVD) at enrollment. An increased risk of CVD events (myocardial infarction, stroke, or cardiovascular death) was apparent for the highest versus the lowest quartile of WHtR (multivariable-adjusted hazard ratio: 1.98) (95% confidence interval: 1.10-3.57; linear trend: p = 0.019) only in the control-diet group, but not in the two groups allocated to intervention with MeDiet (p for interaction = 0.034). This apparent interaction suggesting that the intervention counterbalanced the detrimental cardiovascular effects of adiposity was also significant for body mass index (BMI) (p = 0.01) and waist circumference (p = 0.043). Conclusions: The MeDiet may counteract the harmful effects of increased adiposity on the risk of CVD.
Subject
MESH
Cardiovascular Diseases | Aged, 80 and over | Aged | Spain | Humans | Protective Factors | Middle Aged | Male | Multivariate Analysis | Time Factors | Female | Risk Factors | Adiposity | Proportional Hazards Models | Treatment Outcome | Body Mass Index | Diet, Mediterranean | Obesity, Abdominal | Primary Prevention | Waist Circumference | Incidence
DECS
Índice de Masa Corporal | Dieta Mediterránea | Incidencia | Modelos de Riesgos Proporcionales | Resultado del Tratamiento | Factores de Tiempo | Femenino | Análisis Multivariante | Masculino | Factores Protectores | Circunferencia de la Cintura | Obesidad Abdominal | Factores de Riesgo | Humanos | Persona de Mediana Edad | Anciano | Anciano de 80 o más Años | Prevención Primaria | Enfermedades Cardiovasculares | España | Adiposidad
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