Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20142
Título
Using the Electronic Nose to Identify Airway Infection during COPD Exacerbations
Autor(es)
Fecha de publicación
2015-09-09
Cita
Shafiek H, Fiorentino Rossi F, Merino JL, López-Causapé C, Oliver A, Segura Fuster J, et al. Using the Electronic Nose to Identify Airway Infection during COPD Exacerbations. PLoS One. 2015 Sep 09;10(9):e0135199.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: The electronic nose (e-nose) detects volatile organic compounds (VOCs) in exhaled air. We hypothesized that the exhaled VOCs print is different in stable vs. exacerbated patients with chronic obstructive pulmonary disease (COPD), particularly if the latter is associated with airway bacterial infection, and that the e-nose can distinguish them. Methods: Smell-prints of the bacteria most commonly involved in exacerbations of COPD (ECOPD) were identified in vitro. Subsequently, we tested our hypothesis in 93 patients with ECOPD, 19 of them with pneumonia, 50 with stable COPD and 30 healthy controls in a cross-sectional case-controlled study. Secondly, ECOPD patients were re-studied after 2 months if clinically stable. Exhaled air was collected within a Tedlar bag and processed by a Cynarose 320 e-nose. Breath-prints were analyzed by Linear Discriminant Analysis (LDA) with One Out technique and Sensor logic Relations (SLR). Sputum samples were collected for culture. Results: ECOPD with evidence of infection were significantly distinguishable from non-infected ECOPD (p = 0.018), with better accuracy when ECOPD was associated to pneumonia. The same patients with ECOPD were significantly distinguishable from stable COPD during follow-up (p = 0.018), unless the patient was colonized. Additionally, breath-prints from COPD patients were significantly distinguished from healthy controls. Various bacteria species were identified in culture but the e-nose was unable to identify accurately the bacteria smell-print in infected patients. Conclusion: E-nose can identify ECOPD, especially if associated with airway bacterial infection or pneumonia.
MESH
Aged | Bacterial Infections | Case-Control Studies | Bacteria | Equipment Design | Breath Tests | Pulmonary Disease, Chronic Obstructive | Humans | Middle Aged | Cross-Sectional Studies | Exhalation | Lung | Male | Female | Electronic Nose | Volatile Organic Compounds | Pneumonia
DECS
Espiración | Femenino | Pulmón | Masculino | Nariz Electrónica | Estudios Transversales | Enfermedad Pulmonar Obstructiva Crónica | Compuestos Orgánicos Volátiles | Humanos | Persona de Mediana Edad | Anciano | Infecciones Bacterianas | Neumonía | Pruebas Respiratorias | Diseño de Equipo | Bacterias | Estudios de Casos y Controles
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