Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20133
Title
Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study
Author(s)
Date issued
2015-08-31
Citation
Fernandez-Palomeque C, Grau A, Perello Bestard J, Sanchis P, Isern B, Prieto RM, et al. Relationship between Urinary Level of Phytate and Valvular Calcification in an Elderly Population: A Cross-Sectional Study. PLoS One. 2015 Aug 31;10(8):e0136560.
Language
Inglés
Document type
research article
Abstract
Pathological calcification generally consists of the formation of solid deposits of hydroxyapatite (calcium phosphate) in soft tissues. Supersaturation is the thermodynamic driving force for crystallization, so it is believed that higher blood levels of calcium and phosphate increase the risk of cardiovascular calcification. However several factors can promote or inhibit the natural process of pathological calcification. This cross-sectional study evaluated the relationship between physiological levels of urinary phytate and heart valve calcification in a population of elderly out subjects. A population of 188 elderly subjects (mean age: 68 years) was studied. Valve calcification was measured by echocardiography. Phytate determination was performed from a urine sample and data on blood chemistry, end-systolic volume, concomitant diseases, cardiovascular risk factors, medication usage and food were obtained. The study population was classified in three tertiles according to level of urinary phytate: low (<0.610 mu M), intermediate (0.61-1.21 mu M), and high (>1.21 mu M). Subjects with higher levels of urinary phytate had less mitral annulus calcification and were less likely to have diabetes and hypercholesterolemia. In the multivariate analysis, age, serum phosphorous, leukocytes total count and urinary phytate excretion appeared as independent factors predictive of presence of mitral annulus calcification. There was an inverse correlation between urinary phytate content and mitral annulus calcification in our population of elderly out subjects. These results suggest that consumption of phytate-rich foods may help to prevent cardiovascular calcification evolution.
MESH
Aged | Diabetes Mellitus | Hypercholesterolemia | Leukocyte Count | Heart Valve Diseases | Calcification, Physiologic | Humans | Calcinosis | Mitral Valve | Echocardiography | Aging | Cross-Sectional Studies | Cardiomyopathies | Male | Phosphates | Heart Valves | Phytic Acid | Female | Risk Factors | Durapatite
DECS
Durapatita | Femenino | Cardiomiopatías | Válvulas Cardíacas | Masculino | Ecocardiografía | Estudios Transversales | Ácido Fítico | Factores de Riesgo | Envejecimiento | Calcinosis | Calcificación Fisiológica | Diabetes Mellitus | Humanos | Fosfatos | Enfermedades de las Válvulas Cardíacas | Válvula Mitral | Anciano | Hipercolesterolemia | Recuento de Leucocitos
Online version
DOI
Collections
Full text access