Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20054
Título
Histological Typing in Patients With Cardiac Amyloidosis: JACC Review Topic of the Week.
Autor(es)
Fecha de publicación
2024-03-19
Cita
J Am Coll Cardiol. 2024 Mar 19;83(11):1085-1099.
Idioma
Inglés
Tipo de documento
review article
Resumen
Cardiac amyloidosis is increasingly recognized as a treatable form of heart failure. Highly effective specific therapies have recently become available for the 2 most frequent forms of cardiac amyloidosis: immunoglobulin light chain amyloidosis and transthyretin (ATTR) amyloidosis. Nevertheless, initiation of specific therapies requires recognition of cardiac amyloidosis and appropriate characterization of the amyloid type. Although noninvasive diagnosis is possible for ATTR cardiac amyloidosis, histological demonstration and typing of amyloid deposits is still required for a substantial number of patients with ATTR and in all patients with light chain amyloidosis and other rarer forms of cardiac amyloidosis. Amyloid histological typing can be performed using different techniques: mass spectrometry, immunohistochemistry, and immunoelectron microscopy. This review describes which patients require histological confirmation of cardiac amyloidosis along with when and how to type amyloid deposits in histologic specimens. Furthermore, it covers the characteristics and limitations of the different typing methods that are available in clinical practice.
MESH
Amyloidosis | Heart Failure | Amyloid Neuropathies, Familial | Cardiomyopathies | Humans | Plaque, Amyloid | Amyloid | Immunohistochemistry | Amyloidogenic Proteins | Prealbumin
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- Histological Typing in Patients ...
- Tamaño:
- 4.105Mb
- Formato:
- Descripción:
- Review