Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/20054
Title
Histological Typing in Patients With Cardiac Amyloidosis: JACC Review Topic of the Week.
Author(s)
Date issued
2024-03-19
Citation
J Am Coll Cardiol. 2024 Mar 19;83(11):1085-1099.
Language
Inglés
Document type
review article
Abstract
Cardiac amyloidosis is increasingly recognized as a treatable form of heart failure. Highly effective specific therapies have recently become available for the 2 most frequent forms of cardiac amyloidosis: immunoglobulin light chain amyloidosis and transthyretin (ATTR) amyloidosis. Nevertheless, initiation of specific therapies requires recognition of cardiac amyloidosis and appropriate characterization of the amyloid type. Although noninvasive diagnosis is possible for ATTR cardiac amyloidosis, histological demonstration and typing of amyloid deposits is still required for a substantial number of patients with ATTR and in all patients with light chain amyloidosis and other rarer forms of cardiac amyloidosis. Amyloid histological typing can be performed using different techniques: mass spectrometry, immunohistochemistry, and immunoelectron microscopy. This review describes which patients require histological confirmation of cardiac amyloidosis along with when and how to type amyloid deposits in histologic specimens. Furthermore, it covers the characteristics and limitations of the different typing methods that are available in clinical practice.
MESH
Amyloidosis | Heart Failure | Amyloid Neuropathies, Familial | Cardiomyopathies | Humans | Plaque, Amyloid | Amyloid | Immunohistochemistry | Amyloidogenic Proteins | Prealbumin
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DOI
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