dc.contributor.author | Gonzalez-Lopez, Esther | |
dc.contributor.author | McPhail, Ellen D | |
dc.contributor.author | Salas-Anton, Clara | |
dc.contributor.author | Dominguez, Fernando | |
dc.contributor.author | Gertz, Morie A | |
dc.contributor.author | Dispenzieri, Angela | |
dc.contributor.author | Dasari, Surendra | |
dc.contributor.author | Milani, Paolo | |
dc.contributor.author | Verga, Laura | |
dc.contributor.author | Grogan, Martha | |
dc.contributor.author | Palladini, Giovanni | |
dc.contributor.author | Garcia-Pavia, Pablo | |
dc.date.accessioned | 2024-07-04T10:29:02Z | |
dc.date.available | 2024-07-04T10:29:02Z | |
dc.date.issued | 2024-03-19 | |
dc.identifier.citation | J Am Coll Cardiol. 2024 Mar 19;83(11):1085-1099. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20054 | |
dc.description.abstract | Cardiac amyloidosis is increasingly recognized as a treatable form of heart failure. Highly effective specific therapies have recently become available for the 2 most frequent forms of cardiac amyloidosis: immunoglobulin light chain amyloidosis and transthyretin (ATTR) amyloidosis. Nevertheless, initiation of specific therapies requires recognition of cardiac amyloidosis and appropriate characterization of the amyloid type. Although noninvasive diagnosis is possible for ATTR cardiac amyloidosis, histological demonstration and typing of amyloid deposits is still required for a substantial number of patients with ATTR and in all patients with light chain amyloidosis and other rarer forms of cardiac amyloidosis. Amyloid histological typing can be performed using different techniques: mass spectrometry, immunohistochemistry, and immunoelectron microscopy. This review describes which patients require histological confirmation of cardiac amyloidosis along with when and how to type amyloid deposits in histologic specimens. Furthermore, it covers the characteristics and limitations of the different typing methods that are available in clinical practice. | es_ES |
dc.description.sponsorship | This study has been partially supported by Instituto de Salud Carlos
III through the projects “PI18/0765 and PI20/01379” (cofunded by
European Regional Development Fund/European Social Fund “A way
to make Europe”/“Investing in your future”). The Centro Nacional de
Investigaciones Cardiovasculares is supported by the Instituto de
Salud Carlos III, the Ministerio de Ciencia e Innovación, the ProCentro Nacional de Investigaciones Cardiovasculares Foundation,
and the Severo Ochoa grant (CEX2020-001041-S). This work was also
supported by grants from the Italian Ministry of Health (Ricerca
Finalizzata, grant #GR-2018-12368387), the Italian Ministry of
Research and Education (PRIN 20207XLJB2), Cancer Research UK
4013 (C355/A26819), Fundación Científica Asociación Española Contra
el Cáncer, and AIRC under the Accelerator Award Program. The authors have reported that they have no relationships relevant to the
content of this paper to disclose. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Amyloidosis | es_ES |
dc.subject.mesh | Heart Failure | es_ES |
dc.subject.mesh | Amyloid Neuropathies, Familial | es_ES |
dc.subject.mesh | Cardiomyopathies | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Plaque, Amyloid | es_ES |
dc.subject.mesh | Amyloid | es_ES |
dc.subject.mesh | Immunohistochemistry | es_ES |
dc.subject.mesh | Amyloidogenic Proteins | es_ES |
dc.subject.mesh | Prealbumin | es_ES |
dc.title | Histological Typing in Patients With Cardiac Amyloidosis: JACC Review Topic of the Week. | es_ES |
dc.type | review article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 38479957 | es_ES |
dc.format.volume | 83 | es_ES |
dc.format.number | 11 | es_ES |
dc.format.page | 1085 | es_ES |
dc.identifier.doi | 10.1016/j.jacc.2024.01.010 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Fundación ProCNIC | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1558-3597 | es_ES |
dc.relation.publisherversion | 10.1016/j.jacc.2024.01.010 | es_ES |
dc.identifier.journal | Journal of the American College of Cardiology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Miocardiopatías Hereditarias | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI18/0765 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI20/01379 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |