Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/19520
Title
OLFM4 polymorphisms predict septic shock survival after major surgery
Author(s)
Perez-Garcia, Felipe ISCIII | Resino, Salvador ISCIII | Gómez-Sánchez, Esther | Gonzalo-Benito, Hugo | Fernandez-Rodriguez, Amanda ISCIII | Lorenzo-López, Mario | Heredia-Rodríguez, María | Gómez-Pesquera, Estefanía | Tamayo, Eduardo | Jimenez-Sousa, Maria Angeles ISCIII | Group of Biomedical Research in Critical Care Medicine (BioCritic)
Date issued
2021-04
Citation
Eur J Clin Invest. 2021 Apr;51(4):e13416.
Language
Inglés
Document type
research article
Abstract
Background: Higher expression of olfactomedin-4 (OLFM4), a gene regulated by nuclear factor-kappa B (NF-κB), has been related to a higher risk of organ failure and death in patients with septic shock. We aimed to evaluate the association between OLFM4 single nucleotide polymorphisms (SNPs) and septic shock-related death in 175 patients who underwent major surgery, as well as its performance in predicting mortality. Materials and methods: We carried out a retrospective study. A total of seven OLFM4 SNPs were genotyped by Agena Bioscience's MassARRAY platform. Statistical analysis was performed by Kaplan-Meier and Cox regression tests. The diagnostic performance for predicting septic shock-related death was evaluated by the area under the receiver-operating characteristic (AUROC) curve. Results: Patients with rs17552047 A allele and rs1891944 TT genotype had higher survival than patients with rs17552047 G allele (P-value = .024) and patients with rs1891944 CC/CT genotype (P-value = .038). However, only rs17552047 was associated with a lower risk of death under an additive inheritance model (adjusted hazard ratio [aHR] = 0.44, 95% CI = 0.27-0.71). The multivariate model with the most significant clinical variables (lactate, chronic kidney disease, peritonitis, heart disease and elective surgery) showed an AUROC of 0.776 for predicting septic shock-related death. When we added the OLFM4 rs17552047 SNP to the previous model, the AUROC was 0.811 and was close to reaching significant differences with the previous model (P-value = .065). Conclusion: OLFM4 rs17552047 A allele predicts septic shock survival in patients who underwent major surgery. Furthermore, rs17552047, together with clinical variables, could be useful to predict the outcome of septic shock.
Subject
MESH
Aged | Aged, 80 and over | Area Under Curve | Female | Granulocyte Colony-Stimulating Factor | Humans | Male | Middle Aged | Polymorphism, Single Nucleotide | Postoperative Complications | Prognosis | Proportional Hazards Models | ROC Curve | Retrospective Studies | Shock, Septic | Survival Rate
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DOI
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