Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/19520
Título
OLFM4 polymorphisms predict septic shock survival after major surgery
Autor(es)
Perez-Garcia, Felipe ISCIII | Resino, Salvador ISCIII | Gómez-Sánchez, Esther | Gonzalo-Benito, Hugo | Fernandez-Rodriguez, Amanda ISCIII | Lorenzo-López, Mario | Heredia-Rodríguez, María | Gómez-Pesquera, Estefanía | Tamayo, Eduardo | Jimenez-Sousa, Maria Angeles ISCIII | Group of Biomedical Research in Critical Care Medicine (BioCritic)
Fecha de publicación
2021-04
Cita
Eur J Clin Invest. 2021 Apr;51(4):e13416.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: Higher expression of olfactomedin-4 (OLFM4), a gene regulated by nuclear factor-kappa B (NF-κB), has been related to a higher risk of organ failure and death in patients with septic shock. We aimed to evaluate the association between OLFM4 single nucleotide polymorphisms (SNPs) and septic shock-related death in 175 patients who underwent major surgery, as well as its performance in predicting mortality. Materials and methods: We carried out a retrospective study. A total of seven OLFM4 SNPs were genotyped by Agena Bioscience's MassARRAY platform. Statistical analysis was performed by Kaplan-Meier and Cox regression tests. The diagnostic performance for predicting septic shock-related death was evaluated by the area under the receiver-operating characteristic (AUROC) curve. Results: Patients with rs17552047 A allele and rs1891944 TT genotype had higher survival than patients with rs17552047 G allele (P-value = .024) and patients with rs1891944 CC/CT genotype (P-value = .038). However, only rs17552047 was associated with a lower risk of death under an additive inheritance model (adjusted hazard ratio [aHR] = 0.44, 95% CI = 0.27-0.71). The multivariate model with the most significant clinical variables (lactate, chronic kidney disease, peritonitis, heart disease and elective surgery) showed an AUROC of 0.776 for predicting septic shock-related death. When we added the OLFM4 rs17552047 SNP to the previous model, the AUROC was 0.811 and was close to reaching significant differences with the previous model (P-value = .065). Conclusion: OLFM4 rs17552047 A allele predicts septic shock survival in patients who underwent major surgery. Furthermore, rs17552047, together with clinical variables, could be useful to predict the outcome of septic shock.
Palabras clave
MESH
Aged | Aged, 80 and over | Area Under Curve | Female | Granulocyte Colony-Stimulating Factor | Humans | Male | Middle Aged | Polymorphism, Single Nucleotide | Postoperative Complications | Prognosis | Proportional Hazards Models | ROC Curve | Retrospective Studies | Shock, Septic | Survival Rate
Versión en línea
DOI
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