dc.contributor.author | Simon-Chica, Ana | |
dc.contributor.author | Wülfers, Eike M | |
dc.contributor.author | Kohl, Peter | |
dc.date.accessioned | 2024-05-09T12:40:13Z | |
dc.date.available | 2024-05-09T12:40:13Z | |
dc.date.issued | 2023-09-01 | |
dc.identifier.citation | Am J Physiol Heart Circ Physiol. 2023 Sep 1;325(3):H475-H491. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/19328 | |
dc.description.abstract | Although cardiac action potential (AP) generation and propagation have traditionally been attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable of forming electrically conducting junctions. Interactions between CM and nonmyocytes (NM) enable and modulate each other's activity. This review provides an overview of the current understanding of heterocellular electrical communication in the heart. Although cardiac fibroblasts were initially thought to be electrical insulators, recent studies have demonstrated that they form functional electrical connections with CM in situ. Other NM, such as macrophages, have also been recognized as contributing to cardiac electrophysiology and arrhythmogenesis. Novel experimental tools have enabled the investigation of cell-specific activity patterns in native cardiac tissue, which is expected to yield exciting new insights into the development of novel or improved diagnostic and therapeutic strategies. | es_ES |
dc.description.sponsorship | A.S.-C. received financial support via a “la Caixa” Foundation
under ID 100010434 and PhD Fellowship LCF/BQ/DR19/11740029. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Physiological Society (APS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Myocytes, Cardiac | es_ES |
dc.subject.mesh | Fibroblasts | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Arrhythmias, Cardiac | es_ES |
dc.subject.mesh | Action Potentials | es_ES |
dc.subject.mesh | Electrophysiological Phenomena | es_ES |
dc.title | Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction. | es_ES |
dc.type | review article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 37417876 | es_ES |
dc.format.volume | 325 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | H475 | es_ES |
dc.identifier.doi | 10.1152/ajpheart.00184.2023 | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1522-1539 | es_ES |
dc.relation.publisherversion | 10.1152/ajpheart.00184.2023 | es_ES |
dc.identifier.journal | American journal of physiology. Heart and circulatory physiology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Desarrollo Avanzado sobre Mecanismos y Terapias de las Arritmias | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LCF/BQ/DR19/11740029 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/100010434 | es_ES |