Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/19328
Título
Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction.
Autor(es)
Fecha de publicación
2023-09-01
Cita
Am J Physiol Heart Circ Physiol. 2023 Sep 1;325(3):H475-H491.
Idioma
Inglés
Tipo de documento
review article
Resumen
Although cardiac action potential (AP) generation and propagation have traditionally been attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable of forming electrically conducting junctions. Interactions between CM and nonmyocytes (NM) enable and modulate each other's activity. This review provides an overview of the current understanding of heterocellular electrical communication in the heart. Although cardiac fibroblasts were initially thought to be electrical insulators, recent studies have demonstrated that they form functional electrical connections with CM in situ. Other NM, such as macrophages, have also been recognized as contributing to cardiac electrophysiology and arrhythmogenesis. Novel experimental tools have enabled the investigation of cell-specific activity patterns in native cardiac tissue, which is expected to yield exciting new insights into the development of novel or improved diagnostic and therapeutic strategies.
MESH
Myocytes, Cardiac | Fibroblasts | Humans | Arrhythmias, Cardiac | Action Potentials | Electrophysiological Phenomena
Versión en línea
DOI
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- Nombre:
- Nonmyocytes as electrophysiolo ...
- Tamaño:
- 2.843Mb
- Formato:
- Descripción:
- Review