Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/19328
Title
Nonmyocytes as electrophysiological contributors to cardiac excitation and conduction.
Author(s)
Date issued
2023-09-01
Citation
Am J Physiol Heart Circ Physiol. 2023 Sep 1;325(3):H475-H491.
Language
Inglés
Document type
review article
Abstract
Although cardiac action potential (AP) generation and propagation have traditionally been attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable of forming electrically conducting junctions. Interactions between CM and nonmyocytes (NM) enable and modulate each other's activity. This review provides an overview of the current understanding of heterocellular electrical communication in the heart. Although cardiac fibroblasts were initially thought to be electrical insulators, recent studies have demonstrated that they form functional electrical connections with CM in situ. Other NM, such as macrophages, have also been recognized as contributing to cardiac electrophysiology and arrhythmogenesis. Novel experimental tools have enabled the investigation of cell-specific activity patterns in native cardiac tissue, which is expected to yield exciting new insights into the development of novel or improved diagnostic and therapeutic strategies.
MESH
Myocytes, Cardiac | Fibroblasts | Humans | Arrhythmias, Cardiac | Action Potentials | Electrophysiological Phenomena
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DOI
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