Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/19066
Título
Comparing glycemic traits in defining diabetes among rural Chinese older adults
Autor(es)
Wang, Pin | Li, Yuanjing | Wang, Mingqi | Song, Lin | Dong, Yi | Han, Xiaolei | Tuomilehto, Jaakko ISCIII | Wang, Yongxiang | Du, Yifeng | Qiu, Chengxuan
Fecha de publicación
2024-01
Cita
PLoS One. 2024 Jan 25;19(1):e0296694.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: We sought to identify the optimal cut-off of glycated hemoglobin (HbA1c) for defining diabetes and to assess the agreements of fasting plasma glucose (FPG), fasting serum glucose (FSG), and HbA1c in defining diabetes among rural older adults in China. Methods: This population-based cross-sectional study included 3547 participants (age ≥61 years, 57.8% women) from the Multidomain Interventions to Delay Dementia and Disability in Rural China from 2018-2019; of these, 3122 had no previously diagnosed diabetes. We identified the optimal cut-off of HbA1c against FPG ≥7.0 mmol/L for defining diabetes by using receiver operating characteristic curve and Youden index. The agreements of FPG, FSG, and HbA1c in defining diabetes were assessed using kappa statistics. Results: Among participants without previously diagnosed diabetes (n = 3122), the optimal HbA1c cut-off for defining diabetes was 6.5% (48 mmol/mol), with the sensitivity of 88.9%, specificity of 93.7%, and Youden index of 0.825. The correlation coefficients were 0.845 between FPG and FSG, 0.574 between FPG and HbA1c, and 0.529 between FSG and HbA1c in the total sample (n = 3547). The kappa statistic for defining diabetes was 0.962 between FSG and FPG, and 0.812 between HbA1c and FPG. Conclusions: The optimal cut-off of HbA1c for diagnosing diabetes against FPG >7.0 mmol/L is ≥6.5% in Chinese rural-dwelling older adults. The agreement in defining diabetes using FPG, FSG, and HbA1c is nearly perfect. These results have relevant implications for diabetes research and clinical practice among older adults in China. Clinical trial registration: The protocol of MIND-China was registered in the Chinese Clinical Trial Registry (ChiCTR, www.chictr.org.cn; registration no.: ChiCTR1800017758).
MESH
Blood Glucose | Diabetes Mellitus | Humans | Female | Aged | Middle Aged | Male | Glycated Hemoglobin | Cross-Sectional Studies | Fasting | China
Descripción
The protocol of MIND-China was registered in the Chinese Clinical Trial Registry (ChiCTR, www.chictr.org.cn; registration no.: ChiCTR1800017758).
Versión en línea
DOI
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