Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/18979
Título
Hallmarks of aging: An expanding universe.
Autor(es)
Fecha de publicación
2023-01-19
Cita
Cell . 2023 ;186(2):243-278.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them. We propose the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected among each other, as well as to the recently proposed hallmarks of health, which include organizational features of spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress.
MESH
Versión en línea
DOI
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- hallmarksofaging-2023.pdf
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