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dc.contributor.authorLópez-Otín, Carlos
dc.contributor.authorBlasco, MA 
dc.contributor.authorPartridge, Linda
dc.contributor.authorSerrano, Manuel
dc.contributor.authorKroemer, Guido
dc.date.accessioned2024-03-18T11:08:07Z
dc.date.available2024-03-18T11:08:07Z
dc.date.issued2023-01-19
dc.identifier.citationCell . 2023 ;186(2):243-278.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/18979
dc.description.abstractAging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them. We propose the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected among each other, as well as to the recently proposed hallmarks of health, which include organizational features of spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress.es_ES
dc.description.sponsorshipWe apologize for omitting relevant works and citations due to space constraints. We acknowledge all members of our laboratories for helpful comments during the elaboration of this manuscript. We thank JoseM.P. Freije for critical reading of the manuscript. C.L-O. is supported by grants from the European Research Council (ERC Advanced Grant, DeAge), Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III, and La Caixa Foundation (HR17-00221). The Instituto Universitario de Oncologia is supported by Fundacion Bancaria Caja de Ahorros de Asturias. M.B. is funded by Agencia Estatal de Investigacion (AEI/MCI/10.13039/501100011033, project RETOS SAF2017-82623-R), cofunded by European Regional Development Fund, "A way of making Europe"; Comunidad de Madrid with the Sinergy Project COVIDPREclinicalMODels-CM and the ERC under the European Union's Horizon 2020 research and innovation programme (grant 882385) through the project ERC-AvG SHELTERINS. The CNIO, certified as Severo Ochoa Centre of Excellence by AEI/MCI/10.13039/501100011033, is supported by the Spanish Government through the Instituto de Salud Carlos III. L.P. is supported by Horizon 2020 Framework Programme 741989, the Max Planck Society, and the BBSRC. M.S. is funded by a core grant from the IRB, La Caixa Foundation, the Milky Way Research Foundation, and Secretaria d'Universitats i Recerca del Departament d'Empresa i Coneixement of Catalonia (Grup de Recerca Consolidat 2017 SGR 282). G.K. is supported by the Ligue contre le Cancer (equipe labellisee); Agence National de la Recherche (ANR)-Projets blancs; AMMICa US23/CNRS UMS3655; Association pour la recherche sur le cancer (ARC); Canceropole Ile-de-France; Fondation pour la Recherche Medicale (FRM); a donation by Elior; Equipex Onco-Pheno-Screen; European Joint Programme on Rare Diseases; the European Union Horizon 2020 Projects Oncobiome and Crimson; Fondation Carrefour; Institut National du Cancer; Institut Universitaire de France; LabEx Immuno-Oncology (ANR-18-IDEX-0001); a Cancer Research ASPIRE Award from the Mark Foundation; the RHU Immunolife; Seerave Foundation; SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); and SIRIC Cancer Research and Personalized Medicine (CARPEM). This study contributes to the IdEx Universitede Paris ANR-18-IDEX-0001.es_ES
dc.language.isoenges_ES
dc.publisherCell Press es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.meshAging es_ES
dc.subject.meshCellular Senescence es_ES
dc.subject.meshEpigenesis, Genetices_ES
dc.subject.meshProteostasis es_ES
dc.subject.meshStem Cells es_ES
dc.titleHallmarks of aging: An expanding universe.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID36599349es_ES
dc.format.volume186es_ES
dc.format.number2es_ES
dc.format.page243es_ES
dc.identifier.doi10.1016/j.cell.2022.11.001es_ES
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC) es_ES
dc.contributor.funderFundación La Caixa es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderFundación Bancaria Caja de Ahorros de Asturiases_ES
dc.contributor.funderAgencia Estatal de Investigación (España) es_ES
dc.contributor.funderMax Planck Society es_ES
dc.contributor.funderUK Research and Innovation es_ES
dc.contributor.funderAgence Nationale de la Recherche (Francia) es_ES
dc.contributor.funderGovernment of Catalonia (España) es_ES
dc.contributor.funderFondation ARC pour la recherche sur le cancer es_ES
dc.contributor.funderIdEx Universitede Parises_ES
dc.contributor.funderSIRIC Cancer Research and Personalized Medicine (CARPEM)es_ES
dc.contributor.funderSIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)es_ES
dc.contributor.funderSeerave Foundationes_ES
dc.description.peerreviewedSíes_ES
dc.identifier.e-issn1097-4172es_ES
dc.relation.publisherversionhttps://doi.org/ 10.1016/j.cell.2022.11.001.es_ES
dc.identifier.journalCelles_ES
dc.repisalud.institucionCNIOes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Telómeros y Telomerasaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/882385/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/741989/EUes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/SAF2017-82623-Res_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional