Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/18526
Title
Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.
Author(s)
Date issued
2021-12-27
Language
Inglés
Document type
research article
Abstract
Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (p-value
Subject
MESH
Animals | Blood-Brain Barrier | Brain Infarction | Endocytosis | Gene Ontology | Infarction, Middle Cerebral Artery | Magnetic Resonance Imaging | Male | Nanoparticles | Neuroglobin | Neurons | Neuroprotective Agents | Nitrosative Stress | Oxidative Stress | Principal Component Analysis | Proteomics | Rats, Wistar | Stroke | Survival Analysis | Thiobarbituric Acid Reactive Substances
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