Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/18526
Título
Biological Implications of a Stroke Therapy Based in Neuroglobin Hyaluronate Nanoparticles. Neuroprotective Role and Molecular Bases.
Autor(es)
Fecha de publicación
2021-12-27
Idioma
Inglés
Tipo de documento
research article
Resumen
Exogenous neuroprotective protein neuroglobin (Ngb) cannot cross the blood-brain barrier. To overcome this difficulty, we synthesized hyaluronate nanoparticles (NPs), able to deliver Ngb into the brain in an animal model of stroke (MCAO). These NPs effectively reached neurons, and were microscopically identified after 24 h of reperfusion. Compared to MCAO non-treated animals, those treated with Ngb-NPs showed survival rates up to 50% higher, and better neurological scores. Tissue damage improved with the treatment, but no changes in the infarct volume or in the oxidative/nitrosative values were detected. A proteomics approach (p-value
Palabras clave
MESH
Animals | Blood-Brain Barrier | Brain Infarction | Endocytosis | Gene Ontology | Infarction, Middle Cerebral Artery | Magnetic Resonance Imaging | Male | Nanoparticles | Neuroglobin | Neurons | Neuroprotective Agents | Nitrosative Stress | Oxidative Stress | Principal Component Analysis | Proteomics | Rats, Wistar | Stroke | Survival Analysis | Thiobarbituric Acid Reactive Substances
DOI
Aparece en las colecciones
Acceso a texto completo
Ítems relacionados
Mostrando ítems relacionados por Título, autor o palabras clave.
-
2023-01
research article
Monge Corella, Susana ISCIII; Latasa Zamalloa, Pello; Sierra Moros, María José; et al.