Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/18522
Title
Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review
Author(s)
Picchio, Camila A. | Lens, Sabela | Hernandez-Guerra, Manuel | Arenas, Juan | Andrade, Raúl J. | Crespo, Javier | García-Samaniego, Javier | Romero-Gómez, Manuel | Turnes, Juan | Calleja, José Luis | Simón, Miguel Ángel | White, Trenton M. | Riveiro-Barciela, Mar | Pocurull, Anna | Morales-Arraez, Dalia | Gómez, Alexandra | Buti, Maria | Lazarus, Jeffrey V.
Date issued
2021-12-17
Language
Inglés
Document type
research article
Abstract
Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after significant disease progression face increased risk of severe liver complications and death. Data are scarce on the characteristics and risk factors of people who present late to care in Spain and globally. Data were collected from January 2018 to December 2019 to report late presentation (LP) to specialist care at 11 large university hospitals in Spain to assess related risk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patients were analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reported LP compared to hepatitis B patients (28.1% vs 15.0%; p < 0.001). Older age (p < 0.001), being male (p < 0.001), being Spanish-born (p < 0.001), and having an unknown origin of referral (p = 0.08) were associated with a higher likelihood of LP. Advanced liver disease was identified in 533 (23%) patients and late-stage liver disease in 124 (5.4%). LP, including with irreversible liver damage, to viral hepatitis specialist care is frequent in Spain, despite being a country with unrestricted treatment access. Initiatives to reduce LP should specifically target men, older individuals, foreign-born populations for CHB, and Spanish nationals for CHC.
Subject
Hepatitis C, chronic | Hepatitis B, chronic | Liver disease | Referral and consultation | Disease progression | Hepatitis C crónica | Hepatitis B crónica | Enfermedades hepáticas | Derivación y consulta | Progresión de la enfermedad
MESH
Adult | Aged | Female | Humans | Male | Middle Aged | Retrospective Studies | Spain | Hepatitis B, Chronic | Hepatitis C, Chronic | Hospitals, Teaching | Registries | Logistic Models | Hepatitis C | Liver Diseases | Hepatitis B | Hepacivirus | Referral and Consultation | Disease Progression | Cohort Studies
Online version
DOI
Collections
- Investigación > IIS > IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
- Investigación > IIS > IIS Aragón - Instituto de Investigación Sanitaria Aragón (Aragón)
- Investigación > IIS > IIS BioGipuzkoa - Asociación Instituto de Investigación Sanitaria BioGipuzkoa (País Vasco)
- Investigación > IIS > IDIBAPS - Instituto de Investigaciones Biomédicas August Pi i Sunyer (Cataluña)
- Investigación > IIS > IBIMA-Plataforma BIONAND - Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (Andalucía)
- Investigación > IIS > IBIS - Instituto de Biomedicina de Sevilla (Andalucía)
- Investigación > IIS > IdiPAZ - Instituto de Investigación Sanitaria Hospital La Paz (Madrid)
- Investigación > IIS > IISGS - Instituto de Investigación Sanitaria Galicia Sur (Galicia)
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